Association of PON-1 polymorphism with susceptibility to and severity of ischemic stroke in the Chinese population

Aim: The authors aimed to investigate whether polymorphisms of PON-1 were associated with the susceptibility to and severity of ischemic stroke (IS). Methods: In this study, 302 IS patients and 303 healthy controls were enrolled. Polymorphisms rs854560 and rs854572 of PON-1 were detected using SNaPshot single-nucleotide polymorphism typing technology. Results: The rs854572 polymorphism of the PON-1 gene showed a significant correlation with IS, and its GG genotype reduced the risk of IS (recessive model, p = 0.001). The GG genotype was also associated with mild stroke (p = 0.032). No association was observed between rs854560 and IS. Conclusion: PON-1 rs854572 polymorphism was related to the risk of IS and could be a biomarker to access the severity of IS. Plain language summary Ischemic stroke is a common cerebrovascular disease and genetic factors play an important role in its pathogenesis and progression. PON-1 is an enzyme involved in blood lipid metabolism, and previous studies have found that the PON-1 gene is related to coronary heart disease and other atherosclerotic diseases, while the correlation between PON-1 polymorphism and ischemic stroke remains unclear. The authors compared PON-1 polymorphism between patients with acute ischemic stroke and healthy adults and further investigated the relationship between the PON-1 polymorphism and the severity of ischemic stroke. It was found that PON-1 polymorphism rs854572 was related to the susceptibility to ischemic stroke and the severity of the disease, suggesting that people with risk genotypes should take more active preventive and therapeutic measures.