Suicidality in obsessive compulsive disorder (OCD): A systematic review and meta-analysis

被引:122
作者
Angelakis, Ioannis [1 ]
Gooding, Patricia [2 ]
Tarrier, Nichoas [3 ]
Panagioti, Maria [1 ]
机构
[1] Univ Manchester, Inst Populat Hlth, Manchester M13 9PL, Lancs, England
[2] Univ Manchester, Sch Psychol Sci, Manchester M13 9PL, Lancs, England
[3] Kings Coll London, Inst Psychiat, London WC2R 2LS, England
关键词
Obsessive Compulsive disorder; Suicidality; Systematic review; Meta-analysis; Depression; Comorbidities; POSTTRAUMATIC-STRESS-DISORDER; BODY DYSMORPHIC DISORDER; ANXIETY DISORDERS; PANIC DISORDER; PREVALENCE; COMORBIDITY; RISK; IDEATION; BEHAVIOR; ASSOCIATION;
D O I
10.1016/j.cpr.2015.03.002
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Although a growing number of studies have examined the frequency of suicidal thoughts and behaviors in individuals with obsessive compulsive disorder (OCD), there is controversy about the frequency and burden of suicidality in OCD. This is the first systematic review aimed at examining the association between suicidality and OCD and at providing evidence about psychological mechanisms that may underlie suicidality in those with OCD. Five electronic bibliographic databases were searched up to April 2014: Medline, PsycINFO, Embase, Web of Science and CINAHL. Meta-analysis using random effects models was conducted. Forty-eight studies were included in the systematic review. The pooled effect size across 30 independent comparisons revealed a moderate to high, significant association between suicidality and OCD (Hedges' g = 0.66,95% confidence interval 0.49-0.82) which persisted across different types of suicidality including suicidal ideation and suicide attempts. Comorbid Axis I disorders, increased severity of comorbid depressive and anxiety symptoms, increased severity of obsessions, feelings of hopelessness and past history of suicide attempts were associated with worsening levels of suicidality in OCD. There was no indication for publication bias but the methodological quality of the studies was low. The theoretical, research and clinical implications of these findings are emphasized. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1 / 15
页数:15
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