Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1+/CD31-/CD34- progenitors

被引：46

作者：

Fang, BJ

Shi, MX

Liao, LM

Yang, SG

Liu, YH

Zhao, RC

机构：

[1] Chinese Acad Med Sci, State Key Lab Expt Haematol, Inst Haematol, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[3] Chinese Acad Med Sci, Tissue Engn Ctr, Tianjin 300020, Peoples R China

来源：

JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH | 2003年 / 12卷 / 06期

关键词：

D O I：

10.1089/15258160360732632

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We previously reported that Flk1(+)/CD31(-)/CD34(-) cells isolated from human fetal bone marrow can differentiate at the single cell level into endothelial and hernatopoietic cells in vitro. Here we report that within this cell population reside cells that can differentiate into the epithelium of liver, lung, gut, as well as the cells of both hematopoietic and endothelial system after primary or secondary transplantation into irradiated nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice. Hence, Flk1(+)/CD31(-)/CD34(-) cells possess remarkable differentiation potential and may thereby provide an alternative to hematopoietic stem cells for transplantation. In addition, our results show this stem cell population effectively accelerated wound healing in NOD/SCID mice and thus holds therapeutic promise for treatment of genetic disorders, organ dysfunction, and tissue repair in humans.

引用

页码：603 / 613

页数：11