Associations of cardiovascular risk factors with two surrogate markers of subclinical atherosclerosis: Endothelial function and carotid intima media thickness

被引：28
作者：
Fitch, Kathleen V. [1 ,2 ,3 ]
Stavrou, Eleni [1 ,2 ,3 ]
Looby, Sara E. [1 ,2 ,3 ]
Hemphill, Linda [4 ]
Jaff, Michael R. [5 ]
Grinspoon, Steven K. [1 ,2 ,3 ]
机构：
[1] Massachusetts Gen Hosp, Program Nutr Metab, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Neuroendocrine Unit, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
[4] Massachusetts Gen Hosp, Div Cardiovasc, Boston, MA 02114 USA
[5] Massachusetts Gen Hosp, Vasc Ctr, Boston, MA 02114 USA
来源：
ATHEROSCLEROSIS | 2011年 / 217卷 / 02期
关键词：
Endothelial function; Carotid intima media thickness; Atherosclerosis; DYSFUNCTION; ARTERY; EXPRESSION; IMPACT; MEAL;
D O I：
10.1016/j.atherosclerosis.2011.04.009
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: Endothelial function and carotid intima media thickness (cIMT) were investigated in a cohort of 54 healthy adults without known cardiovascular disease. Methods: Pulse wave amplitude was determined with peripheral arterial tonometry (PAT) to obtain the reactive hyperemia (RH)-PAT ratio. Ultrasound was used to determine cIMT. Results: cIMT and RH-PAT were significantly associated (rho = -0.35, P = 0.02) in univariate analysis. RH-PAT was significantly associated with age, triglycerides, fasting glucose, HDL, WHR, waist circumference and VAT. cIMT was associated with age, smoking history, fasting glucose, systolic blood pressure, diastolic blood pressure and LDL. In multivariate regression analyses, triglyceride level (P = 0.04) remained a significant determinant of RH-PAT whereas systolic blood pressure (P = 0.02) and smoking pack-year history (P = 0.046) were significant determinants of cIMT. Conclusion: Determinants of cIMT and RH-PAT were different, dominated by triglyceride and abdominal adiposity measures for RH-PAT but traditional risk factors including blood pressure, glucose, smoking and LDL for cIMT. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：437 / 440
页数：4
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