BeEAM (bendamustine, etoposide, cytarabine, melphalan) before autologous stem cell transplantation is safe and effective for resistant/relapsed lymphoma patients

被引:102
作者
Visani, Giuseppe [1 ]
Malerba, Lara [1 ]
Stefani, Pietro Maria [2 ]
Capria, Saveria [3 ]
Galieni, Piero [4 ]
Gaudio, Francesco [5 ]
Specchia, Giorgina [5 ]
Meloni, Giovanna [3 ]
Gherlinzoni, Filippo [2 ]
Giardini, Claudio [1 ]
Falcioni, Sadia [4 ]
Cuberli, Francesca [6 ]
Gobbi, Marco [6 ]
Sarina, Barbara [7 ]
Santoro, Armando [7 ]
Ferrara, Felicetto [8 ,9 ]
Rocchi, Marco [10 ]
Ocio, Enrique M. [11 ,12 ]
Dolores Caballero, Maria [11 ,12 ]
Isidori, Alessandro [1 ]
机构
[1] Marche Nord Hosp, Hematol & Stem Cell Transplant Ctr, I-61100 Pesaro, Italy
[2] CaFoncello Hosp, Treviso, Italy
[3] Univ Roma La Sapienza, Dept Biotechnol & Hematol, Rome, Italy
[4] Ascoli Piceno, Ascoli Piceno, Italy
[5] Univ Bari, Sch Med, Div Hematol, Bari, Italy
[6] San Martino Hosp, Genoa, Italy
[7] Ist Clin Humanitas, Dept Hematol & Oncol, Milan, Italy
[8] Cardarelli Hosp, Div Hematol, Naples, Italy
[9] Cardarelli Hosp, Stem Cell Transplantat Unit, Naples, Italy
[10] Univ Urbino, Inst Biomath, I-61029 Urbino, Italy
[11] Univ Salamanca, Univ Hosp, Dept Hematol, E-37008 Salamanca, Spain
[12] Univ Salamanca, Canc Res Ctr IBMCC CSIC, E-37008 Salamanca, Spain
关键词
NON-HODGKINS-LYMPHOMA; HIGH-DOSE CHEMOTHERAPY; BONE-MARROW-TRANSPLANTATION; REGIMEN-RELATED TOXICITY; PHASE-II MULTICENTER; EVERY; WEEKS; B-CELL; SOLID TUMORS; CONVENTIONAL CHEMOTHERAPY; COMBINATION CHEMOTHERAPY;
D O I
10.1182/blood-2011-04-351924
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We designed a phase 1-2 study to evaluate the safety and the efficacy of increasing doses of bendamustine (160 mg/m(2), 180 mg/m2, and 200 mg/m2 given on days -7 and -6) coupled with fixed doses of etoposide, cytarabine, and melphalan (BeEAM regimen) as the conditioning regimen to autologous stem cell transplantation for resistant/relapsed lymphoma patients. Forty-three patients (median age, 47 years) with non-Hodgkin (n = 28) or Hodgkin (n = 15) lymphoma were consecutively treated. Nine patients entered the phase 1 study; no patients experienced a dose-limiting toxicity. Thirty-four additional patients were then treated in the phase 2. A median number of 6 x 10(6) CD34(+) cells/kg (range, 2.4-15.5) were reinfused. All patients engrafted, with a median time to absolute neutrophil count > 0.5 x 10(9)/L of 10 days. The 100-day transplantation-related mortality was 0%. After a median follow-up of 18 months, 35 of 43 patients (81%) are in complete remission, whereas 6 of 43 relapsed and 2 of 43 did not respond. Disease type (non-Hodgkin lymphomas vs Hodgkin disease) and disease status at transplantation (chemosensitive vs chemoresistant) significantly influenced DFS (P = .01; P = .007). Remarkably, 4 of 43 (9%) patients achieved the first complete remission after receiving the high-dose therapy with autologous stem cell transplantation. In conclusion, the new BeEAM regimen is safe and effective for heavily pretreated lymphoma patients. The study was registered at European Medicines Agency (EudraCT number 2008-002736-15). (Blood. 2011;118(12):3419-3425)
引用
收藏
页码:3419 / 3425
页数:7
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