The distinctive biology of cancer in adolescents and young adults

被引：511

作者：

Bleyer, Archie ^{[1
,2
]}

Barr, Ronald ^{[3
]}

Hayes-Lattin, Brandon ^{[4
]}

Thomas, David ^{[5
]}

Ellis, Chad ^{[6
]}

Anderson, Barry ^{[6
]}

机构：

[1] St Charles Hosp, Bend, OR 97701 USA

[2] Natl Childhood Canc Fdn, Arcadia, CA 91006 USA

[3] McMaster Univ, Hamilton, ON L8S 4J9, Canada

[4] Oregon Hlth & Sci Univ, Inst Canc, Portland, OR 97239 USA

[5] Peter MacCallum Canc Inst, Melbourne, Vic 3002, Australia

[6] NCI, Canc Ctr Branch, Canc Therapy Evaluat Program, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1038/nrc2349

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient ( host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.

引用

页码：288 / 298

页数：11

共 61 条

[1]

Al-Jaberi TM, 2003, SAUDI MED J, V24, P871

[2]

ANDERS CK, 2007, J CLIN ONCOL, V25, pS18

[3]

Anderson WF, 2007, J CLIN ONCOL, V25

[4] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history:: A combined analysis of 22 studies [J].

Antoniou, A ;

Pharoah, PDP ;

Narod, S ;

Risch, HA ;

Eyfjord, JE ;

Hopper, JL ;

Loman, N ;

Olsson, H ;

Johannsson, O ;

Borg, Å ;

Pasini, B ;

Radice, P ;

Manoukian, S ;

Eccles, DM ;

Tang, N ;

Olah, E ;

Anton-Culver, H ;

Warner, E ;

Lubinski, J ;

Gronwald, J ;

Gorski, B ;

Tulinius, H ;

Thorlacius, S ;

Eerola, H ;

Nevanlinna, H ;

Syrjäkoski, K ;

Kallioniemi, OP ;

Thompson, D ;

Evans, C ;

Peto, J ;

Lalloo, F ;

Evans, DG ;

Easton, DF .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (05) :1117-1130

[5]

Aricò M, 2003, HAEMATOLOGICA, V88, P747

[6] High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults [J].

Baldus, Claudia D. ;

Burmeister, Thomas ;

Martus, Peter ;

Schwartz, Stefan ;

Goekbuget, Nicola ;

Bloomfield, Clara D. ;

Hoelzer, Dieter ;

Thiel, Eckhard ;

Hofmann, Wolf K. .

JOURNAL OF CLINICAL ONCOLOGY, 2006, 24 (29) :4714-4720

[7] Classification schemes for tumors diagnosed in adolescents and young adults [J].

Barr, RD ;

Holowaty, EJ ;

Birch, JM .

CANCER, 2006, 106 (07) :1425-1430

[8] Young adult oncology: The patients and their survival challenges [J].

Bleyer, Archie .

CA-A CANCER JOURNAL FOR CLINICIANS, 2007, 57 (04) :242-255

[9] Adolescents and young adults with cancer - The scope of the problem and criticality of clinical trials [J].

Bleyer, Archie ;

Budd, Troy ;

Montello, Michael .

CANCER, 2006, 107 (07) :1645-1655

[10]

BLEYER WA, 1975, CANC EPIDEMIOLOGY OL

← 1 2 3 4 5 6 7 →