Arsenic trioxide and ascorbic acid: synergy with potential implications for the treatment of acute myeloid leukaemia?

被引：58
作者：
Bachleitner-Hofmann, T [1 ]
Gisslinger, B [1 ]
Grumbeck, E [1 ]
Gisslinger, H [1 ]
机构：
[1] Univ Vienna, Dept Internal Med 1, Div Haematol & Blood Coagulat, A-1090 Vienna, Austria
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2001年 / 112卷 / 03期
关键词：
acute myeloid leukaemia; arsenic trioxide; ascorbic acid; apoptosis; synergistic effect;
D O I：
10.1046/j.1365-2141.2001.02608.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Arsenic trioxide. (As2O3) induces remission in a high proportion of patients with acute promyelocytic leukaemia (APL) via induction of apoptosis. Preliminary reports suggest that the apoptotic effect of As2O3 is not specific for APL but can also be observed in non-APL acute myeloid leukaemia (AML) cells, although these are less sensitive than APL cells, Ascorbic acid has recently been demonstrated to enhance the apoptotic effect of As2O3. We have therefore evaluated combined As2O3/ascorbic acid treatment in various clinical samples of AML. Our results indicate a significant synergistic effect of As2O3 and ascorbic acid, suggesting a possible future role of As2O3/ascorbic acid combination therapy in patients with AML.
引用
收藏
页码：783 / 786
页数：4
相关论文
共 13 条
[1]   Measurement of spontaneous and therapeutic agent-induced apoptosis with BCL-2 protein expression in acute myeloid leukemia [J].
Banker, DE ;
Groudine, M ;
Norwood, T ;
Appelbaum, FR .
BLOOD, 1997, 89 (01) :243-255
[2]   Pharmacokinetic perspectives on megadoses of ascorbic acid [J].
Blanchard, J ;
Tozer, TN ;
Rowland, M .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1997, 66 (05) :1165-1171
[3]  
Chen GQ, 1997, BLOOD, V89, P3345
[4]  
Chen GQ, 1996, BLOOD, V88, P1052
[5]   Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system [J].
Dai, J ;
Weinberg, RS ;
Waxman, S ;
Jing, YK .
BLOOD, 1999, 93 (01) :268-277
[6]   Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases [J].
Huang, XJ ;
Wiernik, PH ;
Klein, RS ;
Gallagher, RE .
MEDICAL ONCOLOGY, 1999, 16 (01) :58-64
[7]   Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway [J].
Jing, YK ;
Dai, J ;
Chalmers-Redman, RME ;
Tatton, WG ;
Waxman, S .
BLOOD, 1999, 94 (06) :2102-2111
[8]   APOPTOSIS - BASIC BIOLOGICAL PHENOMENON WITH WIDE-RANGING IMPLICATIONS IN TISSUE KINETICS [J].
KERR, JFR ;
WYLLIE, AH ;
CURRIE, AR .
BRITISH JOURNAL OF CANCER, 1972, 26 (04) :239-+
[9]   New retinoids and arsenic compounds for the treatment of refractory acute promyelocytic leukemia: Clinical and basic studies for the next generation [J].
Kitamura, K ;
Kiyoi, H ;
Yoshida, H ;
Tobita, T ;
Takeshita, A ;
Ohno, R ;
Naoe, T .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1997, 40 (Suppl 1) :S36-S41
[10]   INTRAVENOUS ASCORBATE AS A TUMOR CYTOTOXIC CHEMOTHERAPEUTIC AGENT [J].
RIORDAN, NH ;
RIORDAN, HD ;
MENG, X ;
LI, Y ;
JACKSON, JA .
MEDICAL HYPOTHESES, 1995, 44 (03) :207-213
12