Von Willebrand Disease in Pregnancy

被引：10

作者：

Lipe, Brea C.

Dumas, Maura A. ^{[1
]}

Ornstein, Deborah L. ^{[1
,2
]}

机构：

[1] Dartmouth Hitchcock Med Ctr, Hemophilia & Thrombosis Ctr, Sect Hematol Oncol, Lebanon, NH 03756 USA

[2] Dartmouth Med Sch, Dept Med, Hanover, NH 03755 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2011年 / 25卷 / 02期

关键词：

von Willebrand disease; Bleeding disorder; Women; Pregnancy; Delivery; INHERITED BLEEDING DISORDERS; ABO BLOOD-GROUP; FACTOR-VIII; DESMOPRESSIN DDAVP; RISK-FACTORS; WOMEN; DIAGNOSIS; MANAGEMENT; ANESTHESIA; PATIENT;

D O I：

10.1016/j.hoc.2011.01.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Because von Willebrand factor (VWF) levels increase during pregnancy, many women with VWD, though not requiring support with hemostatic agents, are at increased risk for delayed postpartum hemorrhage as coagulation factor levels fall to their prepregnancy levels in the puerperium. Women with moderate or severe disease or complicated pregnancies are best served by delivering at a center with an obstetrician, hematologist, and anesthesiologist experienced in managing coagulation disorders. In addition, on-site laboratory facilities with specialized coagulation testing capability, pharmacy, and blood bank support are critical for success. Ensuring optimal outcomes for pregnant women with VWD requires a multidisciplinary approach.

引用

页码：335 / +

页数：25

共 77 条

[1] Prevalence and risk factors of severe obstetric haemorrhage [J].