Through investigating the status of information management of laboratory equipment in a certain aerospace scientific research unit, analyzing the backwardness of its equipment information management mode, low efficiency and high error rate, this paper puts forward the application of RFID(Radio Frequency Identification) technology in the laboratory, combining visualization, data mining technology and building intelligent equipment information management system. The paper focuses on five functional modules of the system: equipment in-position management, equipment flow information management, equipment resource intelligent allocation management, equipment rights management and equipment life cycle intelligent management. Meanwhile, key technologies involved such as: middleware, mathematical modeling, frequent pattern mining are highlighted. The system has been successfully implemented in an aerospace laboratory and intelligent equipment information management has been realized.