Anti-inflammatory activity and effect on gastric acid secretion of dehydroleucodine isolated from Artemisia douglasiana

被引：26
作者：
Guardia, T [1 ]
Juarez, AO
Guerreiro, E
Guzmán, JA
Pelzer, L
机构：
[1] Natl Univ San Luis, Fac Chem Biochem & Pharm, Pharmacol Unit, Dept Pharm, RA-5700 San Luis, Argentina
[2] Natl Univ San Luis, Fac Chem Biochem & Pharm, Dept Organ Chem, RA-5700 San Luis, Argentina
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 88卷 / 2-3期
关键词：
dehidroleucodine; Artemisia douglasiana; gastric acid; anti-inflammatory activity;
D O I：
10.1016/S0378-8741(03)00211-3
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The effect of Dehydroleucodine (DhL) on gastric acid secretion in rats was investigated at a dose of 40 mg/kg, while its anti-inflammatory effect was investigated in two experimental models: arthritis induced by Freund's adjuvant carrageenan- and cotton pellet-induced granuloma. DhL did not inhibit gastric acid secretion, suggesting that its anti-ulcerogenic effect can be attributed to its action on the mucosa defense factors. On the other hand, DhL inhibited both chronic and acute adjuvant carrageenan-induced inflammation phases, being most effective in the chronic phase. In the granuloma test, DhL also inhibited inflammation. It is suggested that the anti-inflammatory activity of DhL may be attributed to interference with multiple targets on the level of transcription factors, such as NF-kappaB, and cytokines. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：195 / 198
页数：4
相关论文
共 15 条
  • [1] Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappa B
    Bork, PM
    Schmitz, ML
    Kuhnt, M
    Escher, C
    Heinrich, M
    [J]. FEBS LETTERS, 1997, 402 (01) : 85 - 90
  • [2] ESPINAR LA, 1992, ACTA FARM BONAER, V11, P139
  • [3] STRUCTURE ACTIVITY RELATIONSHIP IN THE GASTRIC CYTOPROTECTIVE EFFECT OF SEVERAL SESQUITERPENE LACTONES
    GIORDANO, OS
    PESTCHANKER, MJ
    GUERREIRO, E
    SAAD, JR
    ENRIZ, RD
    RODRIGUEZ, AM
    JAUREGUI, EA
    GUZMAN, J
    MARIA, AOM
    WENDEL, GH
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (13) : 2452 - 2458
  • [4] THE GASTRIC CYTOPROTECTIVE EFFECT OF SEVERAL SESQUITERPENE LACTONES
    GIORDANO, OS
    GUERREIRO, E
    PESTCHANKER, MJ
    GUZMAN, J
    PASTOR, D
    GUARDIA, T
    [J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (04): : 803 - 809
  • [5] MUCUS SYNTHESIS AND SULFHYDRYL-GROUPS IN CYTOPROTECTION MEDIATED BY DEHYDROLEUCODINE, A SESQUITERPENE LACTONE
    GUARDIA, T
    GUZMAN, JA
    PESTCHANKER, MJ
    GUERREIRO, E
    GIORDANO, OS
    [J]. JOURNAL OF NATURAL PRODUCTS, 1994, 57 (04): : 507 - 509
  • [6] HAKANSON R, 1992, YALE J BIOL MED, V65, P761
  • [7] ANTI-INFLAMMATORY ACTIVITY OF SESQUITERPENE LACTONES AND RELATED COMPOUNDS
    HALL, IH
    LEE, KH
    STARNES, CO
    SUMIDA, Y
    WU, RY
    WADDELL, TG
    COCHRAN, JW
    GERHART, KG
    [J]. JOURNAL OF PHARMACEUTICAL SCIENCES, 1979, 68 (05) : 537 - 542
  • [8] Ethnopharmacology of Mexican asteraceae (compositae)
    Heinrich, M
    Robles, M
    West, JE
    de Montellano, BRO
    Rodriguez, E
    [J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1998, 38 : 539 - 565
  • [9] The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-κB by directly targeting p65
    Lyss, G
    Knorre, A
    Schmidt, TJ
    Pahl, HL
    Merfort, I
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (50) : 33508 - 33516
  • [10] MEIER R, 1950, EXPERIENTIA, V6, P468
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