The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus

被引：116

作者：

Xu, Bihua ^{[1
]}

Wang, Shuang ^{[1
]}

Zhou, Mianjing ^{[1
]}

Huang, Yuefang ^{[2
]}

Fu, Rong ^{[1
]}

Guo, Chaohuan ^{[1
]}

Chen, Jingxian ^{[2
]}

Zhao, Jijun ^{[1
]}

Gaskin, Felicia ^{[3
]}

Fu, Shu Man ^{[4
,5
,6
]}

Yang, Niansheng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Rheumatol, Guangzhou 510080, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pediat, Guangzhou 510080, Guangdong, Peoples R China

[3] Univ Virginia, Dept Psychiat & Neurobehav Sci, Charlottesville, VA 22908 USA

[4] Univ Virginia, Dept Med, Div Rheumatol, Charlottesville, VA 22908 USA

[5] Univ Virginia, Ctr Inflammat Immunol & Regenerat Med, Dept Med, Charlottesville, VA 22908 USA

[6] Univ Virginia, Dept Microbiol Immunol & Canc Biol, Charlottesville, VA 22908 USA

来源：

CLINICAL IMMUNOLOGY | 2017年 / 183卷

基金：

中国国家自然科学基金;

关键词：

Tfh; Tfr; SLE; Biomarker; HUMAN BLOOD; TFH CELLS; AUTOIMMUNITY; IL-21; DIFFERENTIATION; ACTIVATION; PHENOTYPE; EXPANSION; SUBSET; BCL-6;

D O I：

10.1016/j.clim.2017.07.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Ffr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：46 / 53

页数：8

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