Utilization of target-specific, hypersensitive strains of Saccharomyces cerevisiae to determine the mode of action of antifungal compounds

被引：4
作者：
Buurman, ET
Andrews, B
Blodgett, AE
Chavda, JS
Schnell, NF
机构：
[1] AstraZeneca R&D Boston, Dept Microbiol, Waltham, MA 02451 USA
[2] AstraZeneca R&D Boston, Dept Mol Sci, Waltham, MA 02451 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 06期
关键词：
D O I：
10.1128/AAC.49.6.2558-2560.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Target-specific hypersusceptible strains of Saccharomyces cerevisiae were used to screen antifungal compounds. Two novel Erg7p inhibitors were identified, providing proof of principle of the approach taken. However, observed hypersensitivities to antifungals acting via other targets imply that use of this tool to identify the mode of action requires significant deconvolution.
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收藏
页码：2558 / 2560
页数：3
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