Identification of a potent and selective 5-HT6 antagonist:: One-step synthesis of (E)-3-(benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile

被引：26

作者：

Wu, YJ

He, H

Hu, SH

Huang, YZ

Scola, PM

Grant-Young, K

Bertekap, RL

Wu, DD

Gao, Q

Li, Y

Klakouski, C

Westphal, RS

机构：

[1] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Neurosci Chem, Wallingford, CT 06492 USA

[2] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Early Discovery Chem, Wallingford, CT 06492 USA

[3] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Neurosci Biol, Wallingford, CT 06492 USA

[4] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Analyt Sci, Wallingford, CT 06492 USA

[5] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Comp Aided Drug Design, Wallingford, CT 06492 USA

[6] Bristol Myers Squibb Co, Pharmaceut Res Inst, Dept Lead Profiling, Wallingford, CT 06492 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 23期

关键词：

D O I：

10.1021/jm034142q

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(E)-3-(Benzenesulfonyl)-2-(methylsulfanyl)pyrido[1,2-alpha]pyrimidin-4-ylidenamine (7) was found to be a potent and selective 5-HT6 antagonist. A one-step synthesis of this compound is described.

引用

页码：4834 / 4837

页数：4

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