A novel intelligent PANI/ PPy@Au@MnO2 yolk - shell nanozyme for MRI-guided 'triple-mode' synergistic targeted anti-tumor therapy

被引：35

作者：

Zhang, Min ^{[1
]}

Li, Baolong ^{[2
]}

Du, Yu ^{[3
]}

Zhou, Gaojian ^{[2
]}

Tang, Yanyan ^{[2
]}

Shi, Yanfen ^{[1
]}

Zhang, BiYu ^{[1
]}

Xu, Zhou ^{[1
]}

Huang, Qingli ^{[1
]}

机构：

[1] Xuzhou Med Univ, Publ Expt Res Ctr, Xuzhou 221004, Jiangsu, Peoples R China

[2] Xuzhou Med Univ, Clin Med Coll 1, Xuzhou 221004, Jiangsu, Peoples R China

[3] Xuzhou Med Univ, Sch Med Technol, Xuzhou 221000, Jiangsu, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2021年 / 424卷

基金：

中国国家自然科学基金;

关键词：

Yolk-shell nanocomposites; Enzymatic; Photothermal performance; Magnetic resonance imaging; Synergistic therapy; PHOTOTHERMAL THERAPY; MANGANESE-DIOXIDE; POLYPYRROLE NANOPARTICLES; CANCER-THERAPY; POLYANILINE; NANOCOMPOSITES; NANOHYBRIDS; GLUTATHIONE; FABRICATION; PROGRESS;

D O I：

10.1016/j.cej.2021.130356

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The preparation and construction of novel nanostructures as targeting theranostic is of great significance for diagnosis and treatment of tumor. Herein, a novel PANI/PPy@Au@MnO2 (PPAuMns) yolk-shell enzymatic theranostic agent was fabricated firstly via in situ deposition of Au nanoparticles (Au NPs) and reduction of KMnO4 on the surface of PANI/PPy nanocomposites. In addition to high biocompatible and biodegraded performance, PPAuMns possessed amazing tumor microenvironment (TME)-responsive O-2 generation capacity, magnetic resonance imaging (MRI) property, enzymatic activity and excellent photothermal conversion effect. Chemotherapeutics doxorubicin and folic acid (FA) were further loaded and decorated on it for targeted tumor therapy. Experiments in vitro and in vivo indicated that DOX-loaded PPAuMns@FA demonstrated excellent synergistic anti-tumor effect combining chemotherapy (CT), chemo-dynamic therapy (CDT) and photothermal therapy (PTT). This work offers a paradigm to design and construct tumor diagnosis and therapy platforms employing TME-responsive synergistic strategy of photothermal ablation, chemo-dynamic and chemotherapy.

引用

页数：13

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