RNA seeds nuclear bodies

被引:18
作者
Carmo-Fonseca, Maria [1 ]
Rino, Jose [1 ]
机构
[1] Univ Nova Lisboa, Inst Mol Med, Fac Med, P-1649028 Lisbon, Portugal
关键词
NONCODING RNAS; VISUALIZATION;
D O I
10.1038/ncb0211-110
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The interior of the eukaryotic cell nucleus is populated by a multitude of microscopic domains termed nuclear bodies. Despite having attracted much attention, how these compartments form and are maintained remained elusive. Now, two live-cell imaging studies provide compelling evidence that nascent RNAs can act as transiently immobilized scaffolds that recruit specific nuclear body proteins.
引用
收藏
页码:110 / 112
页数:3
相关论文
共 15 条
[1]   FLASH and NPAT positive but not Coilin positive Cajal Bodies correlate with cell ploidy [J].
Bongiorno-Borbone, Lucilla ;
De Cola, Antonella ;
Vernole, Patrizia ;
Finos, Livio ;
Barcaroli, Daniela ;
Knight, Richard A. ;
Melino, Gerry ;
De Laurenzi, Vincenzo .
CELL CYCLE, 2008, 7 (15) :2357-2367
[2]   To be or not to be in the nucleolus [J].
Carmo-Fonseca, M ;
Mendes-Soares, L ;
Campos, I .
NATURE CELL BIOLOGY, 2000, 2 (06) :E107-E112
[3]   An Architectural Role for a Nuclear Noncoding RNA: NEAT1 RNA Is Essential for the Structure of Paraspeckles [J].
Clemson, Christine M. ;
Hutchinson, John N. ;
Sara, Sergio A. ;
Ensminger, Alexander W. ;
Fox, Archa H. ;
Chess, Andrew ;
Lawrence, Jeanne B. .
MOLECULAR CELL, 2009, 33 (06) :717-726
[4]   Actin-dependent intranuclear repositioning of an active gene locus in vivo [J].
Dundr, Miroslav ;
Ospina, Jason K. ;
Sung, Myong-Hee ;
John, Sam ;
Upender, Madhvi ;
Ried, Thomas ;
Hager, Gordon L. ;
Matera, A. Gregory .
JOURNAL OF CELL BIOLOGY, 2007, 179 (06) :1095-1103
[5]   From silencing to gene expression: Real-time analysis in single cells [J].
Janicki, SM ;
Tsukamoto, T ;
Salghetti, SE ;
Tansey, WP ;
Sachidanandam, R ;
Prasanth, KV ;
Ried, T ;
Shav-Tal, Y ;
Bertrand, E ;
Singer, RH ;
Spector, DL .
CELL, 2004, 116 (05) :683-698
[6]   De Novo Formation of a Subnuclear Body [J].
Kaiser, Trish E. ;
Intine, Robert V. ;
Dundr, Miroslav .
SCIENCE, 2008, 322 (5908) :1713-1717
[7]   Direct visualization of the co-transcriptional assembly of a nuclear body by noncoding RNAs [J].
Mao, Yuntao S. ;
Sunwoo, Hongjae ;
Zhang, Bin ;
Spector, David L. .
NATURE CELL BIOLOGY, 2011, 13 (01) :95-U227
[8]   Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail [J].
Marzluff, William F. ;
Wagner, Eric J. ;
Duronio, Robert J. .
NATURE REVIEWS GENETICS, 2008, 9 (11) :843-854
[9]   The spliceosome: a self-organized macromolecular machine in the nucleus? [J].
Rino, Jose ;
Carmo-Fonseca, Maria .
TRENDS IN CELL BIOLOGY, 2009, 19 (08) :375-384
[10]   In vivo localization of DNA sequences and visualization of large-scale chromatin organization using lac operator/repressor recognition [J].
Robinett, CC ;
Straight, A ;
Li, G ;
Willhelm, C ;
Sudlow, G ;
Murray, A ;
Belmont, AS .
JOURNAL OF CELL BIOLOGY, 1996, 135 (06) :1685-1700