Correlation of aspirin resistance with serological indicators in patients with coronary heart disease in the plateau

Objective: To explore the incidence rate of aspirin resistance (AR) in patients with coronary heart disease (CHD) in the plateau, and analyze its correlation with clinical influencing factors and serological indicators. Methods: In this retrospective study, 90 patients with CHD who had lived in the plateau for a long time (>10 years) and received treatment were selected as the subjects. Patients were divided into the AR group (11-dehydrothromboxane B2 (11-DH-TXB2) >1500 pg/mg) and aspirin sensitivity group (AS group, 11-DH-TXB2 <= 1.500 pg/mg) according to the content of 11-DH-TXB2 in the urine. The differences in gender, body weight, blood pressure and heart rate between the two groups were compared, and the correlation of these indexes with the incidence rate of AR was analyzed. Moreover, serum indicators were detected. Multiple variable binary logistic regression was used to detect the independent risk factors for AR. Results: The incidence rate of AR in the enrolled patients with CHD was 27.78% (25/90). The body mass index (BMI) in the AR group was significantly higher than that in the AS group (P<0.05). Patients in the AR group had significantly higher C-reactive protein (CRP) and total bilirubin levels and lower mean corpuscular volume and mean corpuscular hemoglobin compared with the AS group (all P<0.05). Binary logistic regression showed that BMI and CRP were independent factors for AR. Conclusion: AR occurs in patients with CHD who take aspirin in the plateau. Patients with high BMI or CRP level have an increased risk of AR. In addition, BMI and CRP are independent factors for AR, and bilirubin can be a predictive factor for AR.