Effect of local delivery of alendronate on bone formation in bioactive glass grafting in rats

被引：47
作者：
Srisubut, Suthasiny
Teerakapong, Arun
Vattraphodes, Theparith
Taweechaisupapong, Suwimol [1 ]
Kaen, Khon
机构：
[1] Khon Kaen Univ, Fac Dent, Dept Oral Diag, Khon Kaen, Thailand
[2] Khon Kaen Univ, Fac Dent, Dept Periodontol, Khon Kaen, Thailand
[3] Khon Kaen Univ, Fac Dent, Dept Oral & Maxillofacial Surg, Khon Kaen, Thailand
[4] Khon Kaen Univ, Fac Dent, Dept Oral Diag, Khon Kaen, Thailand
来源：
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 2007年 / 104卷 / 04期
关键词：
D O I：
10.1016/j.tripleo.2007.04.022
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Objective. The aim of this study was to investigate whether local delivery of alendronate could improve bone formation after bioactive glass grafting in rat mandible. Study design. Twenty- six male Spraque- Dawley rats were divided into control and experimental groups ( 13 rats/ group). A surgical defect was created on the angle of mandible of each animal. In the experimental group, a bioactive glass soaked with the alendronate solution was placed in the bone defect, and in the control group the bioactive glass soaked with saline was used. All animals were killed after 4 weeks. The number of osteoclasts and the amount of new bone formation were evaluated and compared. Results. Four weeks after surgery, the experimental group had significantly more bone formation than the control groups ( P <.05). However, no statistically significant difference was found between the groups when the numbers of osteoclasts were compared. Conclusion. Histologic results showed that a single dose of local delivery of alendronate improves bone formation. However, further studies are required to elucidate the effect of local delivery of alendronate on bone formation in humans.
引用
收藏
页码：E11 / E16
页数：6
相关论文
共 44 条
[1]   DURATION OF THE EFFECTS OF INTRAVENOUS ALENDRONATE IN POSTMENOPAUSAL WOMEN AND IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM AND PAGETS-DISEASE OF BONE [J].
ADAMI, S ;
ZAMBERLAN, N ;
MIAN, M ;
DORIZZI, R ;
ROSSINI, M ;
BRAGA, B ;
GATTI, D ;
BERTOLDO, F ;
LOCASCIO, V .
BONE AND MINERAL, 1994, 25 (02) :75-82
[2]   Alendronate in the treatment of avascular necrosis of the hip [J].
Agarwala, S ;
Sule, A ;
Pai, BU ;
Joshi, VR .
RHEUMATOLOGY, 2002, 41 (03) :346-347
[3]   Systemic alendronate prevents resorption of necrotic bone during revascularization.: A bone chamber study in rats -: art. no. 19 [J].
Åstrand, J ;
Aspenberg, P .
BMC MUSCULOSKELETAL DISORDERS, 2002, 3 (1) :1-5
[4]   Topical, single dose bisphosphonate treatment reduced bone resorption in a rat model for prosthetic loosening [J].
Åstrand, J ;
Aspenberg, P .
JOURNAL OF ORTHOPAEDIC RESEARCH, 2004, 22 (02) :244-249
[5]  
BAYLINK DJ, 1993, J BONE MINER RES, V8, pS565
[6]  
Binderman I, 1991, Curr Opin Dent, V1, P836
[7]   Weekly administration of alendronate: Rationale and plan for clinical assessment [J].
Bone, HG ;
Adami, S ;
Rizzoli, R ;
Favus, M ;
Ross, PD ;
Santora, A ;
Prahalada, S ;
Daifotis, A ;
Orloff, J ;
Yates, J .
CLINICAL THERAPEUTICS, 2000, 22 (01) :15-28
[8]   Bisphosphonate-associated osteonecrosis of the jaws. Report of a case and literature review [J].
Ferreira Leite, Andre ;
Figueiredo, Paulo Tadeu ;
Santos Melo, Nilce ;
Acevedo, Ana Carolina ;
Paraiso Cavalcanti, Marcelo Gusmao ;
Paula, Lilian Marly ;
Paula, Ana Patricia ;
Silva Guerra, Eliete Neves .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2006, 102 (01) :14-21
[9]   Bisphosphonates: Mechanisms of action [J].
Fleisch, H .
ENDOCRINE REVIEWS, 1998, 19 (01) :80-100
[10]  
Furusawa T, 1998, INT J ORAL MAX IMPL, V13, P672
12345