Glucose effectiveness and insulin sensitivity measurements derived from the non-insulin-assisted minimal model and the clamp techniques are concordant

被引：10

作者：

Henriksen, Jan Erik ^{[1
]}

Alford, Frank ^{[2
]}

Ward, Glenn ^{[2
]}

Thye-Ronn, Peter ^{[1
]}

Levin, Klaus ^{[1
]}

Hother-Nielsen, Ole ^{[1
]}

Rantzau, Christian ^{[3
]}

Boston, Ray ^{[4
]}

Beck-Nielsen, Henning ^{[1
]}

机构：

[1] Odense Univ Hosp, Dept Endocrinol M, Diabet Res Ctr, DK-5000 Odense C, Denmark

[2] St Vincent Hosp, Dept Endocrinol & Diabet, Melbourne, Vic, Australia

[3] Univ Melbourne, Heidelberg Repatriat Hosp, Dept Med, Melbourne, Vic, Australia

[4] Univ Penn, NBC, Sch Vet Med, Dept Clin Studies, Philadelphia, PA 19104 USA

来源：

DIABETES-METABOLISM RESEARCH AND REVIEWS | 2010年 / 26卷 / 07期

基金：

英国医学研究理事会;

关键词：

non-insulin unmodified assisted IVGTT; basal insulinaemic eu-hyperglycaemic clamps; SAAM/CONSAM implementation of minimal model; SG; SI; acute insulin release; TOLERANCE TEST; SECRETION; DISPOSAL; INDEX; CELL; SE; HYPERGLYCEMIA; RELATIVES; VOLUME;

D O I：

10.1002/dmrr.1127

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background We investigated the concordance between glucose effectiveness (SG) and insulin sensitivity (SI), derived from the unmodified dynamic non-insulin-assisted intravenous glucose tolerance test (IVGTT) implemented by SG(MM) and SIMM; simulation analysis and modelling/conversational interaction (SAAM/CONSAM) versus the eu/hyperglycaemic basal insulinaemic and the euglycaemic hyperinsulinaemic clamp (SG(CLAMP) and SICLAMP). Methods Twenty-seven of 30 normoglycaemic subjects completed a (1) euglycaemic hyperinsulinaemic clamp, (2) 6-h eu/hyperglycaemic near-normoinsulinaemic pancreatic clamp with hyperglycaemia present over the final 2 h of the clamp (Day 2 study), (3) identical clamp to (2) but with euglycaemia maintained over the entire 6 h (Day 3 study) and (4) IVGTT. SG(CLAMP) was calculated in two ways based on data from study (2) alone (Day 2 SG(CLAMP 210-240')) or from data from study day (2) and (3) (Day 2-3 SG(CLAMP 330-360')). Results SG(MM) was unrelated to the magnitude of endogenous insulin release (AIR). The single-day (Day 2) and two-day (Day 2 and 3) SG(CLAMP) protocols correlated (r = 0.72, p = 0.003), but SG(CLAMP 210-240') was significantly (p = 0.001) higher than SG(CLAMP 330-360'). Employing the Day 2 and 3 SG(CLAMP) protocol, the whole body SG(CLAMP 330-360') was similar to SG(MM) (1.80 +/- 0.82 versus 1.73 +/- 0.58 dL/min) and correlated (r = 0.45, p < 0.02). SG(CLAMP 210-240') did not correlate with SG(MM) (r = 0.24). SIMM and SICLAMP were similar (0.093 +/- 0.060 versus 0.087 +/- 0.029 dL/min per mU/L) and correlated (r = 0.76, p < 0.001). Conclusions The time-dependent increase in glucose disposal observed during a prolonged 6-h clamp significantly influences the estimation of SG(CLAMP), and significant concordance coefficients are observed between SG(MM), and SG(CLAMP 330-360'), and SIMM and SICLAMP. Copyright (C) 2010 John Wiley & Sons, Ltd.

引用

页码：569 / 578

页数：10

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