Significant Increase in 1-Year Posttransplant Renal Arterial Index Predicts Graft Loss

Background and objectives: Conflicting data have been reported concerning the use of kidney graft arterial resistance index (RI) measured by Doppler to predict death-censored graft loss. We hypothesized that changes in RI values could carry better information than a single measure of RI. Design, setting, participants, & measurements: Four hundred twenty-five renal transplant recipients were included in the study. We tested whether changes in renal arterial resistance index between 4 and 12 months after transplant (RI,) were predictive of graft loss. Results: Neither 4-month nor 1-year RI predicted graft loss. The area under the receiver operating characteristics curve of Delta RI4 -> 12 for graft loss was 0.75. A Delta RI4 -> 12 >= 10% had the best sensitivity and specificity. One year after transplant, 22% of the study population had Delta RI4 -> 12 >= 10%. Fifty-five patients (12.9%) experienced graft loss during follow-up. The annual incidence of graft loss was higher in patients with Delta RI4 -> 12 -10 >= 10 (3.5 versus 1.3%; P = 0.009). In multivariate analysis, patients with Delta RI4 -> 12 10% had an increased risk of graft loss (hazard ratio, 6.21; 95% confidence interval, 1.99 to 22.15; P = 0.002). Conclusions: A variation in RI >= 10% in the first year after transplant is an independent risk factor for death-censored graft loss in renal transplant recipients. Clin J Am Soc Nephrol 5: 1867-1872, 2010. doi: 10.2215/CJN.01210210