Induction of hepatic glutathione S-transferase (Pi) activity in rhesus monkey by cadmium

被引：0

作者：

Sidhu, M

Nath, R

机构：

[1] POSTGRAD INST MED EDUC & RES, DEPT EXPTL MED, CHANDIGARH 160012, INDIA

[2] POSTGRAD INST MED EDUC & RES, DEPT BIOCHEM, CHANDIGARH 160012, INDIA

来源：

JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE | 1996年 / 9卷 / 01期

关键词：

cadmium; glutathione S-transferase (Pi); monkey liver induction;

D O I：

10.1002/(SICI)1520-670X(199607)9:1<41::AID-JTRA4>3.0.CO;2-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chronic Cd exposure (25 mg Cd as CdCl2, kg(-1) body wt day(-1) for 10 weeks) was studied on monkey liver glutathione S-transferase (Pi). A significant (209%) increase in GST activity toward EA [substrate of GST (Pi)] was observed. Results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and kinetic analysis indicated the induction of GST (Pi); The induction of GST (Pi) is identical with that observed in preneoplastic nodules generated in rat liver by different models of chemical carcinogenesis. Cadmium chloride can also help in investigating the mechanism of GST (Pi) gene expression in chemical hepatocarcinogenesis.

引用

页码：41 / 46

页数：6

共 50 条

[41] Decreased expression of glutathione S-transferase pi correlates with poorly differentiated grade in patients with oral squamous cell carcinoma
Ma, Hai-long
Yu, Cong
Liu, Ying
Tan, Yi-ran
Qiao, Jin-ke
Yang, Xi
Wang, Li-zhen
Li, Jiang
Chen, Qiong
Chen, Fu-xiang
Zhang, Zhi-yuan
Zhong, Lai-ping
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2015, 44 (03) : 193 - 200
[42] Glutathione S-transferase π localizes in mitochondria and protects against oxidative stress
Goto, Shinji
Kawakatsu, Miho
Izumi, Shin-ichi
Urata, Yoshishige
Kageyama, Kan
Ihara, Yoshito
Koji, Takehiko
Kondo, Takahito
FREE RADICAL BIOLOGY AND MEDICINE, 2009, 46 (10) : 1392 - 1403
[43] Overexpression of glutathione S-transferase π enhances the adduct formation of cisplatin with glutathione in human cancer cells
Goto, S
Iida, T
Cho, S
Oka, M
Kohno, S
Kondo, T
FREE RADICAL RESEARCH, 1999, 31 (06) : 549 - 558
[44] Biomonitoring of the adverse effects induced by the chronic exposure to lead and cadmium on kidney function:: Usefulness of alpha-glutathione S-transferase
Garcon, Guillaume
Leleu, Bruno
Marez, Thierry
Zerimech, Farid
Jean-Marie, Haguenoer D.
Daniel, Furon B.
Shirali, Pirouz
SCIENCE OF THE TOTAL ENVIRONMENT, 2007, 377 (2-3) : 165 - 172
[45] Identification, characterization and expression profiles of Chironomus riparius glutathione S-transferase (GST) genes in response to cadmium and silver nanoparticles exposure
Nair, Prakash M. Gopalakrishnan
Choi, Jinhee
AQUATIC TOXICOLOGY, 2011, 101 (3-4) : 550 - 560
[46] Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
Paweł Surowiak
Verena Materna
Irina Kaplenko
Marek Spaczyński
Manfred Dietel
Hermann Lage
Maciej Zabel
Virchows Archiv, 2005, 447 : 626 - 633
[47] Characterization and expression analysis of glutathione S-transferase genes from an aquatic predator Protohermes costalis (Megaloptera: Corydalidae) on exposure to cadmium
Yang, Jie
Huang, Xingrui
Wen, Fasheng
Huang, Xinglong
Liu, Zhixiao
Zhang, Youxiang
JOURNAL OF ASIA-PACIFIC ENTOMOLOGY, 2023, 26 (02)
[48] Augmented expression of metallothionein and glutathione S-transferase pi as unfavourable prognostic factors in cisplatin-treated ovarian cancer patients
Surowiak, P
Materna, V
Kaplenko, I
Spaczynski, M
Dietel, M
Lage, H
Zabel, M
VIRCHOWS ARCHIV, 2005, 447 (03) : 626 - 633
[49] Significance of nuclear glutathione S-transferase π in resistance to anti-cancer drugs
Goto, S
Kamada, K
Soh, Y
Ihara, Y
Kondo, T
JAPANESE JOURNAL OF CANCER RESEARCH, 2002, 93 (09): : 1047 - 1056
[50] Auxin signalling is involved in cadmium-induced glutathione-S-transferase activity in barley root
Beáta Bočová
Jana Huttová
Igor Mistrík
Ladislav Tamás
Acta Physiologiae Plantarum, 2013, 35 : 2685 - 2690

← 1 2 3 4 5 →