Induction of hepatic glutathione S-transferase (Pi) activity in rhesus monkey by cadmium

被引：0

作者：

Sidhu, M

Nath, R

机构：

[1] POSTGRAD INST MED EDUC & RES, DEPT EXPTL MED, CHANDIGARH 160012, INDIA

[2] POSTGRAD INST MED EDUC & RES, DEPT BIOCHEM, CHANDIGARH 160012, INDIA

来源：

JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE | 1996年 / 9卷 / 01期

关键词：

cadmium; glutathione S-transferase (Pi); monkey liver induction;

D O I：

10.1002/(SICI)1520-670X(199607)9:1<41::AID-JTRA4>3.0.CO;2-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chronic Cd exposure (25 mg Cd as CdCl2, kg(-1) body wt day(-1) for 10 weeks) was studied on monkey liver glutathione S-transferase (Pi). A significant (209%) increase in GST activity toward EA [substrate of GST (Pi)] was observed. Results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and kinetic analysis indicated the induction of GST (Pi); The induction of GST (Pi) is identical with that observed in preneoplastic nodules generated in rat liver by different models of chemical carcinogenesis. Cadmium chloride can also help in investigating the mechanism of GST (Pi) gene expression in chemical hepatocarcinogenesis.

引用

页码：41 / 46

页数：6

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