Induction of hepatic glutathione S-transferase (Pi) activity in rhesus monkey by cadmium

被引：0

作者：

Sidhu, M

Nath, R

机构：

[1] POSTGRAD INST MED EDUC & RES, DEPT EXPTL MED, CHANDIGARH 160012, INDIA

[2] POSTGRAD INST MED EDUC & RES, DEPT BIOCHEM, CHANDIGARH 160012, INDIA

来源：

JOURNAL OF TRACE ELEMENTS IN EXPERIMENTAL MEDICINE | 1996年 / 9卷 / 01期

关键词：

cadmium; glutathione S-transferase (Pi); monkey liver induction;

D O I：

10.1002/(SICI)1520-670X(199607)9:1<41::AID-JTRA4>3.0.CO;2-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of chronic Cd exposure (25 mg Cd as CdCl2, kg(-1) body wt day(-1) for 10 weeks) was studied on monkey liver glutathione S-transferase (Pi). A significant (209%) increase in GST activity toward EA [substrate of GST (Pi)] was observed. Results of sodium dodecyl sulfate-polyacrylamide gel electrophoresis and kinetic analysis indicated the induction of GST (Pi); The induction of GST (Pi) is identical with that observed in preneoplastic nodules generated in rat liver by different models of chemical carcinogenesis. Cadmium chloride can also help in investigating the mechanism of GST (Pi) gene expression in chemical hepatocarcinogenesis.

引用

页码：41 / 46

页数：6

共 50 条

[21] Responses of glutathione and glutathione S-transferase to cadmium and mercury exposure in pedunculate oak (Quercus robur) leaf discs
Gullner, G
Uotila, M
Komives, T
BOTANICA ACTA, 1998, 111 (01): : 62 - 65
[22] α-Tocopherol inhibits human glutathione S-transferase π
van Haaften, RIM
Evelo, CTA
Haenen, GRMM
Bast, A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (03) : 631 - 633
[23] Effect of abiotic stresses on glutathione peroxidase and glutathione S-transferase activity in barley root tips
Haluskova, L'ubica
Valentovicova, Katarina
Huttova, Jana
Mistrik, Igor
Tamas, Ladislav
PLANT PHYSIOLOGY AND BIOCHEMISTRY, 2009, 47 (11-12) : 1069 - 1074
[24] Effect of Dietary Cadmium on the Activity of Glutathione S-Transferase and Carboxylesterase in Different Developmental Stages of the Oxya chinensis (Orthoptera: Acridoidea)
Zhang, Y. P.
Song, D. N.
Wu, H. H.
Yang, H. M.
Zhang, J. Z.
Li, L. J.
Ma, E. B.
Guo, Y. P.
ENVIRONMENTAL ENTOMOLOGY, 2014, 43 (01) : 171 - 177
[25] Differential catalytic efficiency of allelic variants of human glutathione S-transferase Pi in catalyzing the glutathione conjugation of thiotepa
Srivastava, SK
Singhal, SS
Hu, X
Awasthi, YC
Zimniak, P
Singh, SV
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1999, 366 (01) : 89 - 94
[26] Glutathione S-transferase π: a potential role in antitumor therapy
Dong, Shu-Chen
Sha, Huan-Huan
Xu, Xiao-Yue
Hu, Tian-Mu
Lou, Rui
Li, Huizi
Wu, Jian-Zhong
Dan, Chen
Feng, Jifeng
DRUG DESIGN DEVELOPMENT AND THERAPY, 2018, 12 : 3535 - 3547
[27] S-Glutathionylation of Keap1: a new role for glutathione S-transferase pi in neuronal protection
Carvalho, Andreia Neves
Marques, Carla
Guedes, Rita C.
Castro-Caldas, Margarida
Rodrigues, Elsa
van Horssen, Jack
Gama, Maria Joao
FEBS LETTERS, 2016, 590 (10) : 1455 - 1466
[28] Comparative study of effects of cadmium cations in free and chelated forms on activity of glutathione S-transferase, growth, and endocytosis in culture of the infusoriumTetrahymena pyriformis
I. V. Shemarova
E. B. Maizel’
A. E. Khovanskikh
Journal of Evolutionary Biochemistry and Physiology, 2000, 36 : 111 - 117
[29] Glutathione S-transferase pi expression regulates the Nrf2-dependent response to hormetic diselenides
Bartolini, D.
Commodi, J.
Piroddi, M.
Incipini, L.
Sancineto, L.
Santi, C.
Galli, F.
FREE RADICAL BIOLOGY AND MEDICINE, 2015, 88 : 466 - 480
[30] Influence of glutathione S-transferase pi and p53 expression on tumor frequency and spectrum in mice
Gate, L
Majumdar, RS
Lunk, A
Tew, KD
INTERNATIONAL JOURNAL OF CANCER, 2005, 113 (01) : 29 - 35

← 1 2 3 4 5 →