Effects of latex avoidance on latex sensitization, atopy and allergic diseases in patients with spina bifida

被引：29

作者：

Blumchen, K. ^{[1
]}

Bayer, P. ^{[1
]}

Buck, D. ^{[1
]}

Michael, T. ^{[2
]}

Cremer, R. ^{[3
]}

Fricke, C. ^{[4
]}

Henne, T. ^{[5
]}

Peters, H. ^{[6
]}

Hofmann, U. ^{[7
]}

Keil, T. ^{[8
]}

Schlaud, M. ^{[9
]}

Wahn, U. ^{[1
]}

Niggemann, B. ^{[1
]}

机构：

[1] Charite, Dept Pediat Pneumol & Immunol, D-13353 Berlin, Germany

[2] Charite, Social Pediat Ctr, D-13353 Berlin, Germany

[3] Childrens Hosp, Cologne, Germany

[4] Werner Otto Inst, Hamburg, Germany

[5] Childrens Hosp Altona, Hamburg, Germany

[6] Ctr Pediat Neurol Dis, Mainz, Germany

[7] Childrens Hosp Auf der Bult, Dept Pediat Surg, Hannover, Germany

[8] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[9] Robert Koch Inst, Dept Epidemiol & Hlth Reporting, D-1000 Berlin, Germany

来源：

ALLERGY | 2010年 / 65卷 / 12期

关键词：

atopy; latex; prevention; sensitization; spina bifida; RISK-FACTORS; FOLLOW-UP; PREVALENCE; CHILDREN; ASTHMA; IMMUNOTHERAPY; PREVENTION; POLLEN; IGE;

D O I：

10.1111/j.1398-9995.2010.02447.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Background: Ten years ago, avoidance measures such as the performance of latex-free operations were implemented in children with spina bifida. Since then, latex sensitization and latex allergy have decreased in this high-risk group. Objective: To study the effect of primary latex-free prophylaxis on the prevalence of allergic diseases and atopy as a marker for sensitization spreading in children with spina bifida. Methods: One hundred and twenty children with spina bifida born after the introduction of latex-free prophylaxis and operated on under latex-free conditions ('current group') were examined for latex sensitization, latex allergy, sensitization to aero- and food allergens and allergic diseases. Results were compared to a 'historic' (not latex-free operated) group of children with spina bifida and comparable age (n = 87) and to a recent sample of children from the general population (n = 12 403). Results: In comparison with the 'historic group', latex sensitization (55% vs 5%, P < 0.001) and latex allergy (37% vs 0.8%, P < 0.001) were significantly reduced in the 'current group'. Furthermore, a significant reduction could be demonstrated for sensitization to aeroallergens (41.4% vs 20.8%, P = 0.001) and for allergic diseases (35% vs 15%, P = 0.001). The prevalence for atopy, sensitization to aero-/foodallergens and for allergic diseases in children of the 'current group' was similar to those in children of the weighted population sample. Conclusions: Latex avoidance in children with spina bifida prevents latex sensitization and latex allergy. Additionally, it also seems to prevent sensitization to other allergens and allergic diseases which might be explained by the prevention of sensitization spreading.

引用

页码：1585 / 1593

页数：9

共 35 条

[11] Spina bifida as an independent risk factor for sensitization to latex [J].

Hochleitner, BW ;

Menardi, G ;

Häussler, B ;

Ulmer, H ;

Kofler, H ;

Reider, N .

JOURNAL OF UROLOGY, 2001, 166 (06) :2370-2373

[12] Allergy testing in children:: why, who, when and how? [J].

Host, A ;

Andrae, S ;

Charkin, S ;

Diaz-Vázquez, C ;

Dreborg, S ;

Eigenmann, PA ;

Friedrichs, F ;

Grinsted, P ;

Lack, G ;

Meylan, G ;

Miglioranzi, P ;

Muraro, A ;

Nieto, A ;

Niggemann, B ;

Pascual, C ;

Pouech, MG ;

Rancé, F ;

Rietschel, E ;

Wickman, M .

ALLERGY, 2003, 58 (07) :559-569

[13] The pattern of atopic sensitization is associated with the development of asthma in childhood [J].

Illi, S ;

von Mutius, E ;

Lau, S ;

Nickel, R ;

Niggermann, B ;

Sommerfeld, C ;

Wahn, U .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) :709-714

[14] Prevalence of latex sensitization and allergy in Portuguese children [J].

Jorge, Arminda ;

Lorente, Felix ;

Taborda-Barata, Luis .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 2006, 17 (06) :466-473

[15] Extractable latex allergens in airborne glove powder and in cut glove pieces [J].

Kujala, V ;

Alenius, H ;

Palosuo, T ;

Karvonen, J ;

Pfäffli, P ;

Reijula, K .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (07) :1077-1081

[16] The challenge of comprehensively mapping children's health in a nation-wide health survey:: Design of the German KiGGS-study [J].

Kurth, Baerbel-Maria ;

Kamtsiuris, Panagiotis ;

Hoelling, Heike ;

Schlaud, Martin ;

Doelle, Ruediger ;

Ellert, Ute ;

Kahl, Heidrun ;

Knopf, Hiltraud ;

Lange, Michael ;

Mensink, Gert B. M. ;

Neuhauser, Hannelore ;

Rosario, Angelika Schaffrath ;

Scheidt-Nave, Christa ;

Schenk, Liane ;

Schlack, Robert ;

Stolzenberg, Heribert ;

Thamm, Michael ;

Thierfelder, Wulf ;

Wolf, Ute .

BMC PUBLIC HEALTH, 2008, 8 (1)

[17] Specific IgE response to purified and recombinant allergens in latex allergy [J].

Kurup V.P. ;

Sussman G.L. ;

Yeang H.Y. ;

Elms N. ;

Breiteneder H. ;

Arif S.A.M. ;

Kelly K.J. ;

Bansal N.K. ;

Fink J.N. .

Clinical and Molecular Allergy, 3 (1)

[18] Sensitivity and allergy to latex in atopic and non-atopic children [J].

Liebke, C ;

Niggemann, B ;

Wahn, U .

PEDIATRIC ALLERGY AND IMMUNOLOGY, 1996, 7 (02) :103-107

[19] GATA3-driven Th2 responses inhibit TGF-β1-induced FOXP3 expression and the formation of regulatory T cells [J].

Mantel, Pierre-Yves ;

Kuipers, Harmjan ;

Boyman, Onur ;

Rhyner, Claudio ;

Ouaked, Nadia ;

Ruckert, Beateru ;

Karagiannidis, Christian ;

Lambrecht, Bart N. ;

Hendriks, Rudolf W. ;

Crameri, Reto ;

Akdis, Cezmi A. ;

Blaser, Kurt ;

Schmidt-Weber, Carsten B. .

PLOS BIOLOGY, 2007, 5 (12) :2847-2861

[20]

Michael T, 1996, CLIN EXP ALLERGY, V26, P934

← 1 2 3 4 →