Mobocertinib: A Potential Treatment for nscLc with eGfRexon 20 Insertions

被引：11

作者：

Pacheco, Jose M. ^{[1
]}

机构：

[1] Univ Colorado Anschutz Canc Ctr, Dept Internal Med, Div Med Oncol, Aurora, CO USA

来源：

CANCER DISCOVERY | 2021年 / 11卷 / 07期

关键词：

D O I：

10.1158/2159-8290.CD-21-0379

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Amivantamab is the only FDA-approved therapy for non-small cell lung cancer (NSCLC) with EGFR exon 20 insertions. Unfortunately, patients eventually develop progression of disease on this therapy, and most do not respond to this treatment. In this issue of Cancer Discovery, Gonzalvez and colleagues and Riely and colleagues highlight preclinical and early clinical data supporting mobocertinib as a potentially efficacious agent for NSCLC with EGFR exon 20 insertions.

引用

页码：1617 / 1619

页数：3

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