Regeneration-based therapies for spinal cord injuries

被引：24
作者：
Okano, Hideyuki
Kaneko, Shinjiro
Okada, Seiji
Iwanami, Akio
Nakamura, Masaya
Toyama, Yoshiaki
机构：
[1] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, Tokyo 1608582, Japan
[2] Keio Univ, Sch Med, Dept Orthoped Surg, Tokyo 1608582, Japan
[3] Harvard Univ, Childrens Hosp, Sch Med, Div Neurosci, Boston, MA 02115 USA
[4] Kyushu Univ, Grad Sch Med Sci, SSP Stem Cell Unit, Higashi Ku, Fukuoka 8128582, Japan
[5] Natl Hosp Org, Clin Res Ctr, Murayama Med Ctr, Tokyo 2080011, Japan
来源：
NEUROCHEMISTRY INTERNATIONAL | 2007年 / 51卷 / 2-4期
基金：
日本科学技术振兴机构;
关键词：
interleukin-6 (IL-6); neural stem cells; reactive astrocytes; semaphorin; 3A; spinal cord injury (SCI); stat3;
D O I：
10.1016/j.neuint.2007.04.013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Although it has been long believed that the damaged central nervous system does not regenerate upon injury, there is an emerging hope for regeneration-based therapy of the damaged central nervous system (CNS) due to the progress of developmental biology and regenerative medicine including stem cell biology. In this review, we have summarized recent studies aimed at the development of regeneration-based therapeutic approaches for spinal cord injuries, including therapy with anti-inflammatory cytokines, transplantation of neural stem/precursor cells and induction of axonal regeneration. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：68 / 73
页数：6
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