Orthopoxvirus IL-18 binding proteins: Affinities and antagonist activities

被引：55

作者：

Calderara, S ^{[1
]}

Xiang, Y ^{[1
]}

Moss, B ^{[1
]}

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

VIROLOGY | 2001年 / 279卷 / 01期

关键词：

D O I：

10.1006/viro.2000.0689

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The affinities of purified recombinant human IL-18 binding protein (BP) and ectromelia and cowpox virus homologs for human and murine IL-18 were compared by plasmon resonance. The dissociation constants of human IL-18BP were similar for murine and human IL-18. By contrast, the dissociation constants of the viral proteins for murine IL-18 were 12- to 50-fold lower than that for human IL-18. The ectromelia and cowpox virus proteins were biologically active, as judged by their ability to inhibit induction of interferon-gamma by murine and human IL-18. The relative affinities of the orthopoxvirus IL-18BPs are consistent with the rodent host range of the viruses. (C) 2001 Academic Press.

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页码：22 / 26

页数：5

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