Depression and Pharmacogenetics

被引:3
作者
Ampong, David Nana [1 ]
机构
[1] Univ Alaska Anchorage, Nursing, Coll Hlth, Sch Nursing, 3321 Providence DR, Anchorage, AK 99508 USA
关键词
Pharmacogenomics; Pharmacogenetics; Pharmacokinetic; Pharmacodynamics; P-glycoprotein; Adenosine-triphosphate binding cassette (ABC); MAJOR DEPRESSION; METAANALYSIS;
D O I
10.1016/j.apnu.2017.10.011
中图分类号
R47 [护理学];
学科分类号
1011 ;
摘要
Depression is the most common and leading devastating psychiatric illness that affects a majority of the world population. The treatment of depression has been a challenge for a majority of patients and healthcare practitioners. The advent of pharmacogenomics (PGx) empowered the Food and Drug Administration to approve some antidepressant biomarkers for PGx model of treatment. The PGx testing identifies whether an individual is a poor metabolizer, ultra/rapid metabolizer, intermediate metabolizer, or essential metabolizer of an antidepressants before prescription. This is a cutting edge treatment that eliminates trial and error. PGx testing has shown to precisely identify the effective medication and dose for a patient.
引用
收藏
页码:71 / 74
页数:4
相关论文
共 17 条
  • [1] [Anonymous], 2015, Depression
  • [2] Brigitta Bondy, 2002, Dialogues Clin Neurosci, V4, P7
  • [3] Evaluation of Genomic Applications in Practice and Prevention, 2015, EGAPP WORK GROUP REC
  • [4] Foley Kevin F, 2010, MLO Med Lab Obs, V42, P32
  • [5] Pharmacogenomics of antidepressant drugs
    Horstmann, Sonja
    Binder, Elisabeth B.
    [J]. PHARMACOLOGY & THERAPEUTICS, 2009, 124 (01) : 57 - 73
  • [6] Kerr M., 2012, Depression and college students
  • [7] Kyu-Man H., 2013, PSYCHIAT INVEST, V10, P286
  • [8] Pharmacogenetic polymorphisms and response to escitalopram and venlafaxine over 8 weeks in major depression
    Ng, Chee
    Sarris, Jerome
    Singh, Ajeet
    Bousman, Chad
    Byron, Keith
    Peh, Lai Huat
    Smith, Deidre Joy
    Tan, Chay Hoon
    Schweitzer, Isaac
    [J]. HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, 2013, 28 (05) : 516 - 522
  • [9] Pharmacogenetics in major depression: A comprehensive meta-analysis
    Niitsu, Tomihisa
    Fabbri, Chiara
    Bentini, Francesco
    Serretti, Alessandro
    [J]. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2013, 45 : 183 - 194
  • [10] Human P-glycoprotein differentially affects antidepressant drug transport: relevance to blood-brain barrier permeability
    O'Brien, Fionn E.
    Clarke, Gerard
    Dinan, Timothy G.
    Cryan, John F.
    Griffin, Brendan T.
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2013, 16 (10) : 2259 - 2272