Trial Design: How Do We Figure Out if an AED Works

被引：8
|
作者：
French, Jacqueline A. [1 ]
机构：
[1] NYU, Sch Med, Dept Neurol, New York, NY 10016 USA
来源：
EPILEPSY CURRENTS | 2012年 / 12卷 / 01期
关键词：
RANDOMIZED CONTROLLED-TRIAL; PARTIAL EPILEPSY; PARTIAL SEIZURES; STIMULATION; LAMOTRIGINE; OXCARBAZEPINE; CARBAMAZEPINE; TOPIRAMATE; GABAPENTIN; EFFICACY;
D O I：
10.5698/1535-7511-12.1.24
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Regulatory trials rigorously test the ability of a treatment to impact a known outcome, such as seizure frequency, as measured in well-controlled trials. Such outcomes are called efficacy outcomes. Sometimes these measured outcomes do not reflect the true effectiveness of the drug in the clinic. This article provides some examples of how this can happen and also discusses trials intended to measure effectiveness.
引用
收藏
页码：24 / 26
页数：3
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