The psychological impact of testing for thrombophilia: a systematic review

被引:44
作者
Cohn, D. M. [1 ]
Vansenne, F. [2 ]
Kaptein, A. A. [3 ]
De Borgie, C. A. J. M. [2 ]
Middeldorp, S. [4 ,5 ]
机构
[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol Biostatist & Bioinformat, NL-1105 AZ Amsterdam, Netherlands
[3] Leiden Univ, Med Ctr, Psychol Unit, Leiden, Netherlands
[4] Leiden Univ, Med Ctr, Dept Clin Epidemiol, Leiden, Netherlands
[5] Leiden Univ, Med Ctr, Vasc Med Unit, Dept Endocrinol & Gen Internal Med, Leiden, Netherlands
关键词
anxiety; psychological stress; thrombophilia;
D O I
10.1111/j.1538-7836.2008.03005.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Nowadays, large numbers of patients are tested for thrombophilia, even though the benefits of this strategy remain unclear. A potential disadvantage of this predominantly genetic testing is the psychological impact, including fear, depression and worry. Objectives: To systematically review studies that determined the nature and extent of the psychological impact of testing for thrombophilia. Patients/methods: We searched the MEDLINE data base (1966-2008), the EMBASE data base (1985-2008) and the PsychInfo data base (1806-2008) for relevant trials, without language restrictions. Bibliographies of relevant articles were scanned for additional articles. We reviewed all relevant studies that focused on the psychological impact of testing for thrombophilia. Only full papers of studies that included 15 patients or more were considered eligible for this review. Two reviewers independently extracted data and assessed quality. Results: Six studies fulfilled the eligibility criteria. As these studies varied appreciably in methodology, the pooling of data was not possible. Studies of psychological impact of genetic testing for thrombophilia report few negative results, although most assessments were limited to short-term follow-up, or lacked methodological accuracy. Conclusions: No valid conclusions can be drawn about the psychological impact of genetic testing in patients based on the current available literature. Given the large number of patients that are being exposed to testing for thrombophilia, and the uncertain benefits, there is an urgent need for more uniformity in the measurement of the psychological impact of thrombophilia testing.
引用
收藏
页码:1099 / 1104
页数:6
相关论文
共 39 条
[1]  
Alderson P., 2002, COCHRANE COLLABORATI
[2]   Social aspects of genetic testing for factor V leiden mutation in healthy individuals and their importance for daily practice [J].
Bank, I ;
Scavenius, MPRB ;
Büller, HR ;
Middeldorp, S .
THROMBOSIS RESEARCH, 2004, 113 (01) :7-12
[3]   MUTATION IN BLOOD-COAGULATION FACTOR-V ASSOCIATED WITH RESISTANCE TO ACTIVATED PROTEIN-C [J].
BERTINA, RM ;
KOELEMAN, BPC ;
KOSTER, T ;
ROSENDAAL, FR ;
DIRVEN, RJ ;
DERONDE, H ;
VANDERVELDEN, PA ;
REITSMA, PH .
NATURE, 1994, 369 (6475) :64-67
[4]   No association between the common MTHFR 677C→T polymorphism and venous thrombosis -: Results from the MEGA study [J].
Bezemer, Irene D. ;
Doggen, Carine J. M. ;
Vos, Hans L. ;
Rosendaal, Frits R. .
ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (05) :497-501
[5]  
Bonadona V, 2002, CANCER EPIDEM BIOMAR, V11, P97
[6]  
BOVILL EG, 1989, BLOOD, V73, P712
[7]   Thrombophilia and venous thromboembolism: Implications for testing [J].
Cohn, Danny M. ;
Roshani, Sara ;
Middeldorp, Saskia .
SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2007, 33 (06) :573-581
[8]  
COHN DM, 2007, J THROMB HAEMOST S2, V5, pP7470
[9]   Current practise of testing for inherited thrombophilia [J].
Coppens, M. ;
Van Mourik, J. A. ;
Eckmann, C. M. ;
Buller, H. R. ;
Middeldorp, S. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (09) :1979-1981
[10]   Homocysteine, MTHFR and risk of venous thrombosis:: a meta-analysis of published epidemiological studies [J].
Den Heijer, M ;
Lewington, S ;
Clarke, R .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2005, 3 (02) :292-299