Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

被引：612

作者：

Dey, Anwesha ^{[1
]}

Varelas, Xaralabos ^{[2
]}

Guan, Kun-Liang ^{[3
,4
]}

机构：

[1] Genentech Inc, Dept Discovery Oncol, San Francisco, CA 94080 USA

[2] Boston Univ, Sch Med, Dept Biochem, Boston, MA 02118 USA

[3] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS DRUG DISCOVERY | 2020年 / 19卷 / 07期

关键词：

YES-ASSOCIATED PROTEIN; STEM-CELL PROLIFERATION; TRANSCRIPTION FACTOR TEAD; TUMOR-SUPPRESSOR PATHWAY; SMALL-MOLECULE INHIBITOR; SIGNALING PATHWAY; YAP ACTIVATION; TISSUE-GROWTH; INTESTINAL REGENERATION; PROGNOSTIC-SIGNIFICANCE;

D O I：

10.1038/s41573-020-0070-z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

In this Review, Dey and colleagues discuss the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discuss new strategies and therapeutic implications of targeting this pathway. The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in organ development, epithelial homeostasis, tissue regeneration, wound healing and immune modulation. Many of these roles are mediated by the transcriptional effectors YAP and TAZ, which direct gene expression via control of the TEAD family of transcription factors. Dysregulated Hippo pathway and YAP/TAZ-TEAD activity is associated with various diseases, most notably cancer, making this pathway an attractive target for therapeutic intervention. This Review highlights the key findings from studies of Hippo pathway signalling across biological processes and diseases, and discusses new strategies and therapeutic implications of targeting this pathway.

引用

页码：480 / 494

页数：15

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