Assembly and trafficking of P2X purinergic receptors (Review)

被引：42

作者：

Murrell-Lagnado, Ruth D. ^{[1
]}

Qureshi, Omar S. ^{[2
]}

机构：

[1] Univ Cambridge, Dept Pharmacol, Cambridge CB2 1PD, England

[2] Univ Birmingham, MRC, Ctr Immune Regulat, Birmingham, W Midlands, England

来源：

MOLECULAR MEMBRANE BIOLOGY | 2008年 / 25卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

P2X purinergic receptors; assembly; trafficking;

D O I：

10.1080/09687680802050385

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P2X receptors are cation selective ion channels gated by the binding of extracellular ATP. Seven subtypes have been identified and they have widespread and overlapping distributions throughout the body. They form homo- and heterotrimeric complexes that differ in their functional properties and subcellular localization. They form part of larger signalling complexes, interacting with unrelated ion channels and other membrane and cytosolic proteins. Up- or down-regulation of their expression is associated with several disease states. This review aims to summarize recent work on the assembly and trafficking of this family of receptors.

引用

页码：321 / U15

页数：13

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