mTOR links environmental signals to T cell fate decisions

被引:62
作者
Chapman, Nicole M. [1 ]
Chi, Hongbo [1 ]
机构
[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA
来源
FRONTIERS IN IMMUNOLOGY | 2015年 / 5卷
关键词
mTOR; T cells; iNKT cell; T-reg cells; ACUTE LYMPHOBLASTIC-LEUKEMIA; HYPOXIA-INDUCIBLE FACTOR-1; PATHOGENIC T(H)17 CELLS; AMINO-ACID TRANSPORTER; RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET; TUBEROUS SCLEROSIS; NATURAL-KILLER; PROTEIN-KINASE; CUTTING EDGE;
D O I
10.3389/fimmu.2014.00686
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell fate decisions play an integral role in maintaining the health of organisms under homeostatic and inflammatory conditions. The localized microenvironment in which developing and mature T cells reside provides signals that serve essential functions in shaping these fate decisions. These signals are derived from the immune compartment, including antigens, co-stimulation, and cytokines, and other factors, including growth factors and nutrients. The mechanistic target of rapamycin (mTOR), a vital sensor of signals within the immune microenvironment, is a central regulator of T cell biology. In this review, we discuss how various environmental cues tune mTOR activity in T cells, and summarize how mTOR integrates these signals to influence multiple aspects of T cell biology.
引用
收藏
页码:1 / 11
页数:11
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