Immune checkpoint inhibitors in the onset of myasthenia gravis with hyperCKemia

被引：28

作者：

Takamatsu, Koutaro ^{[1
]}

Nakane, Shunya ^{[1
,2
]}

Suzuki, Shigeaki ^{[3
]}

Kosaka, Takayuki ^{[1
]}

Fukushima, Satoshi ^{[4
]}

Kimura, Toshihiro ^{[4
]}

Miyashita, Azusa ^{[4
]}

Mukaino, Akihiro ^{[1
]}

Yamakawa, Shiori ^{[1
]}

Watanabe, Keisuke ^{[1
]}

Jinnin, Masatoshi ^{[4
]}

Komohara, Yoshihiro ^{[5
]}

Ihn, Hironobu ^{[4
]}

Ando, Yukio ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Neurol, Fac Life Sci, Kumamoto, Japan

[2] Kumamoto Univ Hosp, Dept Mol Neurol & Therapeut, Kumamoto, Japan

[3] Keio Univ, Dept Neurol, Sch Med, Tokyo, Japan

[4] Kumamoto Univ, Grad Sch Med Sci, Dept Dermatol & Plast Surg, Fac Life Sci, Kumamoto, Japan

[5] Kumamoto Univ, Grad Sch Med Sci, Dept Cell Pathol, Fac Life Sci, Kumamoto, Japan

来源：

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY | 2018年 / 5卷 / 11期

基金：

日本学术振兴会;

关键词：

DILATED CARDIOMYOPATHY; UNTREATED MELANOMA; NIVOLUMAB; IPILIMUMAB; THERAPY; AUTOANTIBODIES; PATIENT; SUSCEPTIBILITY; ASSOCIATION; CTLA4;

D O I：

10.1002/acn3.654

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Immune checkpoint inhibitors sometimes cause neuromuscular adverse events. Although a few cases of myasthenia gravis with hyperCKemia triggered by immune checkpoint inhibitors have been described, conclusive evidence remains limited. We conducted a systematic review of published cases of myasthenia gravis with hyperCKemia related to immune checkpoint inhibitors. Moreover, we tested anti-striational antibodies in the case of myasthenia gravis with myositis after nivolumab administration. We located 17 published case reports. Anti-striational antibodies were tested in six cases and five cases were positive. Our systematic analyses revealed poor prognosis in myasthenia gravis combined hyperCKemia with immune checkpoint inhibitors.

引用

页码：1421 / 1427

页数：7

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