Twenty-four-hour control with latanoprost-timolol-fixed combination therapy vs latanoprost therapy

被引:58
作者
Konstas, AGP
Boboridis, K
Tzetzi, D
Kallinderis, K
Jenkins, JN
Stewart, WC
机构
[1] Pharmaceut Res Network LLC, Charleston, SC 29407 USA
[2] Univ Thessaloniki, Australasian Hellen Educ Progress Assoc Hosp, Dept Ophthalmol, Glaucoma Unit, GR-54006 Thessaloniki, Greece
[3] Univ S Carolina, S Carolina Eye Inst, Columbia, SC 29208 USA
关键词
D O I
10.1001/archopht.123.7.898
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To evaluate the 24-hour efficacy and safety of the latanoprost-timolol maleate-fixed combination vs latanoprost therapy in patients with primary open-angle glaucoma. Methods: A prospective, observer-masked, crossover, active-controlled, randomized comparison in which after a 6-week medicine-free period, patients were randomized to either latanoprost-timolol-fixed combination therapy or latanoprost therapy, both dosed once each evening, alone for 8 weeks., Patients were then switched to the opposite treatment for 8 weeks. At the end of the washout and treatment periods, a 24-hour diurnal curve was performed. Results: The baseline untreated mean +/- SD diurnal curve in 37 patients who completed the study was 24.2 +/- 2.0 mm Hg. The mean diurnal curve was 19.2 +/- 2.6 mm Hg for those who received latanoprost therapy alone and 16.7 +/- 2.1 mm Hg for those who received the fixed combination therapy (P <.001). The fixed combination therapy also provided a lower absolute intraocular pressure level (1.5-2.9 mm Hg, P<.001) and a greater intraocular pressure reduction from the untreated baseline (P<.001). Stinging was statistically lower with latanoprost therapy alone (P=.04), but itching was statistically increased compared with the fixed combination therapy (P=.04). Conclusion: The result of this study suggests that the latanoprost-timolol-fixed combination compared with latanoprost therapy alone provides improved intraocular pressure reduction over the 24-hour diurnal curve and for each individual time point in patients with primary open-angle glaucoma.
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页码:898 / 902
页数:5
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