Berberine and ginsenoside Rg3 act synergistically via the MAPK/ERK pathway in nasopharyngeal carcinoma cells

被引：9

作者：

Zhou, Fangliang ^{[1
,2
,3
,4
]}

Hu, Jing ^{[2
,4
]}

Dai, Na ^{[2
,4
]}

Song, Lan ^{[1
,2
,3
]}

Lin, Ting ^{[2
,4
]}

Liu, Jie ^{[2
,4
]}

Li, Kairui ^{[2
,4
]}

Peng, Zhuang ^{[3
]}

He, Yingchun ^{[1
,2
,4
]}

Liao, Duan-fang ^{[3
]}

机构：

[1] Hunan Univ Chinese Med, Coll Med, Changsha 410208, Peoples R China

[2] Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha 410208, Peoples R China

[3] Hunan Prov Key Lab Qual Evaluat Bulk Herbs, Changsha 410208, Peoples R China

[4] Hunan Prov Engn & Technol Res Ctr Prevent & Treat, Changsha 410208, Peoples R China

来源：

JOURNAL OF FUNCTIONAL FOODS | 2020年 / 66卷

基金：

中国国家自然科学基金;

关键词：

Berberine; Ginsenoside Rg3; Synergistic action; Nasopharyngeal carcinoma cells; MAPK/ERK Pathway; IN-VITRO; PROLIFERATION; CANCER; APOPTOSIS; GROWTH; PHOSPHORYLATION; HYDROCHLORIDE; INDUCTION; PROTEIN;

D O I：

10.1016/j.jff.2020.103802

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Herein, we investigated the effects of combining berberine (Ber; the major active constituent of Rhizoma coptidis) with ginsenoside Rg3 (Rg3; an active ingredient of Panax ginseng) on the proliferation and apoptosis of nasopharyngeal carcinoma (NPC) cells, and explored the underlying mechanism. Combining Ber with Rg3 synergistically inhibited the proliferation of NPC CNE2 cells in vitro and in vivo. Additionally, Ber combined with Rg3 induced apoptosis by promoting the expression of apoptosis-related protein Box, and inhibiting the expression of Survivin, PCNA and anti-apoptotic protein Bcl-2. Ber combined with Rg3 plays a role in anti-NPC through MAPK/ERK pathway. Ber combined with Rg3 is a potent natural combination agent with potential for treating and preventing NPC.

引用

页数：11

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