Drug discovery: Fresh hope to can the worms

被引：28

作者：

Prichard, Roger K. ^{[1
]}

Geary, Timothy G. ^{[1
]}

机构：

[1] McGill Univ, Inst Parasitol, Ste Anne De Bellevue, PQ H9X 3V9, Canada

来源：

NATURE | 2008年 / 452卷 / 7184期

关键词：

D O I：

10.1038/452157a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Parasitic worms kill many livestock, and the drugs used against them are becoming less effective. The discovery of a class of compounds that kills worms resistant to existing drugs is thus a welcome development.

引用

页码：157 / 158

页数：2

共 6 条

[1] Synthesis and anthelmintic activity of substituted (R)-phenyllactic acid containing cyclohexadepsipeptides [J].

Jeschke, Peter ;

Benet-Buchholz, Jordi ;

Harder, Achim ;

Etzel, Winfried ;

Schindler, Michael ;

Gau, Wolfgang ;

Weiss, Hans-Christoph .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (16) :4410-4415

[2] A new class of anthelmintics effective against drug-resistant nematodes [J].

Kaminsky, Ronald ;

Ducray, Pierre ;

Jung, Martin ;

Clover, Ralph ;

Rufener, Lucien ;

Bouvier, Jacques ;

Weber, Sandra Schorderet ;

Wenger, Andre ;

Wieland-Berghausen, Susanne ;

Goebel, Thomas ;

Gauvry, Noelle ;

Pautrat, Francois ;

Skripsky, Thomas ;

Froelich, Olivier ;

Komoin-Oka, Clarisse ;

Westlund, Bethany ;

Sluder, Ann ;

Maeser, Pascal .

NATURE, 2008, 452 (7184) :176-U19

[3] Mode of action of levamisole and pyrantel, Anthelmintic Resistance, E153 and Q57 [J].

Martin, R. J. ;

Robertson, A. P. .

PARASITOLOGY, 2007, 134 :1093-1104

[4] Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana:: a two-phase epidemiological study [J].

Osei-Atweneboano, Mike Y. ;

Eng, Jeffrey K. L. ;

Boakye, Daniel A. ;

Gyapong, John O. ;

Prichard, Roger K. .

LANCET, 2007, 369 (9578) :2021-2029

[5] Activation of nicotinic receptors uncouples a developmental timer from the molting timer in C-elegans [J].

Ruaud, Anne-Francoise ;

Bessereau, Jean-Louis .

DEVELOPMENT, 2006, 133 (11) :2211-2222

[6] Drug resistance in veterinary helminths [J].

Wolstenholme, AJ ;

Fairweather, I ;

Prichard, R ;

von Samson-Himmelstjerna, G ;

Sangster, NC .

TRENDS IN PARASITOLOGY, 2004, 20 (10) :469-476

← 1 →