Ketamine-New Possibilities in the Treatment of Depression: A Narrative Review

被引：11

作者：

Kowalczyk, Mateusz ^{[1
]}

Kowalczyk, Edward ^{[2
]}

Kwiatkowski, Pawel ^{[3
]}

Lopusiewicz, Lukasz ^{[4
]}

Sienkiewicz, Monika ^{[5
]}

Talarowska, Monika ^{[6
]}

机构：

[1] Babinski Mem Hosp, Aleksandrowska St 159, PL-91229 Lodz, Poland

[2] Med Univ Lodz, Dept Pharmacol & Toxicol, Zeligowskiego St 7-9, PL-90752 Lodz, Poland

[3] Pomeranian Med Univ, Dept Diagnost Immunol, Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland

[4] West Pomeranian Univ Technol Szczecin, Fac Food Sci & Fisheries, Ctr Bioimmobilisat & Innovat Packaging Mat, Janickiego 35, PL-71270 Szczecin, Poland

[5] Med Univ Lodz, Dept Pharmaceut Microbiol & Microbiol Diagnost, Muszynskiego St 1, PL-90151 Lodz, Poland

[6] Univ Lodz, Inst Psychol, Dept Clin Psychol & Psychopathol, Smugowa St 10-12, PL-91433 Lodz, Poland

来源：

LIFE-BASEL | 2021年 / 11卷 / 11期

关键词：

ketamine; depression; anxiety; NMDA receptor; neurodegeneration; GABA; COVID-19; pandemic; TREATMENT-RESISTANT DEPRESSION; AMINO-ACID RECEPTORS; FACTOR; KINASE; INTRANASAL ESKETAMINE; ORAL ANTIDEPRESSANT; SUICIDAL IDEATION; DOUBLE-BLIND; GLUTAMATE; ANTAGONIST; EFFICACY;

D O I：

10.3390/life11111186

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The SARS-CoV-2 coronavirus epidemic has led to an increase in the number of people with depression. Symptoms related to the mental sphere (mainly depression and anxiety) may be experienced by one third of the worldwide population. This entails the need for the effective and rapid treatment of depressive episodes. An effective drug seems to be s-ketamine, which was accepted in March 2019 by the Food and Drug Administration (FDA) for the treatment of drug-resistant depression. This drug provides a quick antidepressant effect with maximum effectiveness achieved after 24 h. It also appears to reduce the occurrence of suicidal thoughts. However, research into undesirable effects, especially in groups of people susceptible to psychotic episodes or those who use alcohol or psychoactive substances, is necessary.

引用

页数：11

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