Environmental endocrine disruptors: does a sex-related susceptibility exist?

被引:17
作者
Bulzomi, Pamela [1 ]
Marino, Maria [1 ]
机构
[1] Univ Roma Tre, Dept Biol, I-00146 Rome, Italy
来源
FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷
关键词
Endocrine disruptors; Plant-derived flavonoids; gender differences; Estrogen; Estrogen receptors; Androgen; Androgen receptor; signal transduction pathways; Review; ESTROGEN-RECEPTOR-ALPHA; SIGNAL-TRANSDUCTION PATHWAY; SEXUALLY DIMORPHIC NUCLEUS; DIOXIN-LIKE CHEMICALS; BREAST-CANCER RISK; ANDROGEN RECEPTOR; PROSTATE-CANCER; BISPHENOL-A; GENE-EXPRESSION; IN-UTERO;
D O I
10.2741/3867
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Several substances present in the environment, now classified as endocrine disruptors (EDs), strongly interfere with both androgen and oestrogen actions in reproductive tissues. However, nowadays it is well recognized that these sex steroid hormones are more than regulators of gonadal functions. In fact, they, in synergy with genes, are responsible of sex-related differences in anatomical, physiological, and behavioral traits which characterize males and females of many vertebrate species, including humans. Thus, even if EDs are present in minute amount (part for trillion) in environment, their effects in male and female physiology could be greater than before expected also prejudicing the sex-steroid hormone-induced integrated physiological responses in women and men. In addition, differences in male and female susceptibility to EDs could be present even if scarce information on this aspect is still available. Here we have reviewed the state of the art on the sex-related susceptibility to EDs underlying the mechanism at the root of these effects.
引用
收藏
页码:2478 / 2498
页数:21
相关论文
共 198 条
[1]   3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor α [J].
Abdelrahim, M ;
Ariazi, E ;
Kim, K ;
Khan, S ;
Barhoumi, R ;
Burghardt, R ;
Liu, SX ;
Hill, D ;
Finnell, R ;
Wlodarczyk, B ;
Jordan, VC ;
Safe, S .
CANCER RESEARCH, 2006, 66 (04) :2459-2467
[2]   Survival versus apoptotic 17β-estradiol effect:: Role of ERα and ERβ activated non-genornic signaling [J].
Acconcia, F ;
Totta, P ;
Ogawa, S ;
Cardillo, I ;
Inoue, S ;
Leone, S ;
Trentalance, A ;
Muramatsu, M ;
Marino, M .
JOURNAL OF CELLULAR PHYSIOLOGY, 2005, 203 (01) :193-201
[3]   Palmitoylation-dependent estrogen receptor α membrane localization:: Regulation by 17β-estradiol [J].
Acconcia, F ;
Ascenzi, P ;
Bocedi, A ;
Spisni, E ;
Tomasi, V ;
Trentalance, A ;
Visca, P ;
Marino, M .
MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (01) :231-237
[4]   Transgenerational effects of the endocrine disruptor vinclozolin on the prostate transcriptome and adult onset disease [J].
Anway, Matthew D. ;
Skinner, Michael K. .
PROSTATE, 2008, 68 (05) :517-529
[5]   Androgen receptor or estrogen receptor-β blockade alters DHEA-, DHT-, and E2-induced proliferation and PSA production in human prostate cancer cells [J].
Arnold, Julia T. ;
Liu, Xunxian ;
Allen, Jeffrey D. ;
Le, Hanh ;
McFann, Kimberly K. ;
Blackman, Marc R. .
PROSTATE, 2007, 67 (11) :1152-1162
[6]  
Ascenzi Paolo, 2006, Molecular Aspects of Medicine, V27, P299, DOI 10.1016/j.mam.2006.07.001
[7]   Interactions of methoxyacetic acid with androgen receptor [J].
Bagchi, Gargi ;
Hurst, Christopher H. ;
Waxman, David J. .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2009, 238 (02) :101-110
[8]   Alpha-fetoprotein protects the developing female mouse brain from masculinization and defeminization by estrogens [J].
Bakker, J ;
De Mees, C ;
Douhard, Q ;
Balthazart, J ;
Gabant, P ;
Szpirer, J ;
Szpirer, C .
NATURE NEUROSCIENCE, 2006, 9 (02) :220-226
[9]   The aryl hydrocarbon receptor complex and the control of gene expression [J].
Beischlag, Timothy V. ;
Morales, J. Luis ;
Hollingshead, Brett D. ;
Perdew, Gary H. .
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 2008, 18 (03) :207-250
[10]   COMPLETE ANDROGEN INSENSITIVITY DUE TO MUTATIONS IN THE PROBABLE ALPHA-HELICAL SEGMENTS OF THE DNA-BINDING DOMAIN IN THE HUMAN ANDROGEN RECEPTOR [J].
BEITEL, LK ;
PRIOR, L ;
VASILIOU, DM ;
GOTTLIEB, B ;
KAUFMAN, M ;
LUMBROSO, R ;
ALVARADO, C ;
MCGILLIVRAY, B ;
TRIFIRO, M ;
PINSKY, L .
HUMAN MOLECULAR GENETICS, 1994, 3 (01) :21-27