Absence of Neuronal Response Modulation with Familiarity in Perirhinal Cortex

被引：0

作者：

Baruchin, Liad J. ^{[1
]}

Ranson, Adam ^{[2
]}

Good, Mark ^{[3
]}

Crunelli, Vincenzo ^{[1
,4
]}

机构：

[1] Cardiff Univ, Sch Biosci, Neurosci Div, Cardiff, S Glam, Wales

[2] Cardiff Univ, Neurosci & Mental Hlth Res Inst, Cardiff CF24 4HQ, S Glam, Wales

[3] Cardiff Univ, Dept Psychol, Cardiff, S Glam, Wales

[4] Malta Univ, Dept Physiol & Biochem, Msida, Malta

来源：

NEUROSCIENCE | 2018年 / 394卷

基金：

英国惠康基金;

关键词：

memory; medial temporal lobe; ensemble recordings; visual evoked potentials; VISUAL RECOGNITION MEMORY; FORNIX TRANSECTION; NEUROTOXIC LESIONS; DECLARATIVE MEMORY; INFORMATION; OBJECT; RAT; HIPPOCAMPAL; PLASTICITY; MODEL;

D O I：

10.1016/j.neuroscience.2018.10.020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The perirhinal cortex (PRH) is considered a crucial cortical area for familiarity memory and electrophysiological studies have reported the presence of visual familiarity encoding neurons in PRH. However, recent evidence has questioned the existence of these neurons. Here, we used a visual task in which head-restrained mice were passively exposed to oriented gratings or natural images. Evoked potentials and single-unit recordings showed evoked responses to novelty in V1 under some conditions. However, the PRH showed no response modulation with respect to familiarity under a variety of different conditions or retention delays. These results indicate that the PRH does not contribute to familiarity/novelty encoding using passively exposed visual stimuli. (C) 2018 The Author(s). Published by Elsevier Ltd on behalf of IBRO.

引用

页码：23 / 29

页数：7

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