Bioactive Ceramic Scaffolds for Bone Tissue Engineering by Powder Bed Selective Laser Processing: A Review

被引：44
作者：
Kamboj, Nikhil [1 ]
Ressler, Antonia [2 ]
Hussainova, Irina [1 ]
机构：
[1] Tallinn Univ Technol, Dept Mech & Ind Engn, Ehitajate Tee 5, EE-19086 Tallinn, Estonia
[2] Univ Zagreb, Fac Chem Engn & Technol, Marulicev Trg 19,Pp 177, HR-10001 Zagreb, Croatia
来源：
MATERIALS | 2021年 / 14卷 / 18期
关键词：
additive manufacturing; bone tissue engineering; ceramics; calcium phosphate; calcium silicate; critical-sized defects; drugs; laser powder bed fusion; scaffolds; selective laser melting; selective laser sintering; MESENCHYMAL STEM-CELLS; IN-VIVO PERFORMANCE; DRUG-DELIVERY; MECHANICAL-PROPERTIES; GLASS SCAFFOLDS; HYDROXYAPATITE COMPOSITES; PHOSPHATE SCAFFOLDS; CALCIUM PHOSPHATES; SUSTAINED-RELEASE; OSTEOGENIC CELLS;
D O I：
10.3390/ma14185338
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The implementation of a powder bed selective laser processing (PBSLP) technique for bioactive ceramics, including selective laser sintering and melting (SLM/SLS), a laser powder bed fusion (L-PBF) approach is far more challenging when compared to its metallic and polymeric counterparts for the fabrication of biomedical materials. Direct PBSLP can offer binder-free fabrication of bioactive scaffolds without involving postprocessing techniques. This review explicitly focuses on the PBSLP technique for bioactive ceramics and encompasses a detailed overview of the PBSLP process and the general requirements and properties of the bioactive scaffolds for bone tissue growth. The bioactive ceramics enclosing calcium phosphate (CaP) and calcium silicates (CS) and their respective composite scaffolds processed through PBSLP are also extensively discussed. This review paper also categorizes the bone regeneration strategies of the bioactive scaffolds processed through PBSLP with the various modes of functionalization through the incorporation of drugs, stem cells, and growth factors to ameliorate critical-sized bone defects based on the fracture site length for personalized medicine.
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页数：27
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