Immunosuppressant-induced Endothelial Damage and Pulmonary Arterial Hypertension

被引：18

作者：

Mathew, Rajamma ^{[1
]}

Huang, Jing ^{[1
]}

Katta, Umadevi S. ^{[3
]}

Krishnan, Usha ^{[1
]}

Sandoval, Claudio ^{[2
]}

Gewitz, Michael H. ^{[1
]}

机构：

[1] Maria Fareri Childrens Hosp, Westchester Med Ctr, New York Med Coll, Sect Cardiol,Dept Pediat, Valhalla, NY USA

[2] Maria Fareri Childrens Hosp, Westchester Med Ctr, New York Med Coll, Dept Pathol, Valhalla, NY USA

[3] Maria Fareri Childrens Hosp, Westchester Med Ctr, New York Med Coll, Sect Hematol & Oncol,Dept Pediat, Valhalla, NY USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2011年 / 33卷 / 01期

关键词：

immunosuppressants; endothelial cells; acute respiratory distress syndrome; pulmonary arterial hypertension; STEM-CELL TRANSPLANTATION; VASCULAR SMOOTH-MUSCLE; CAVEOLAE; PROLIFERATION; CALCINEURIN; EXPRESSION; DISEASE; INJURY;

D O I：

10.1097/MPH.0b013e3181ec0ede

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclosporine A, used to prevent graft-versus-host-disease, is known to induce endothelial injury. Endothelial dysfunction is an important feature of pulmonary arterial hypertension (PAH). In this article, we describe 2 children who developed cyclosporine-induced acute respiratory distress syndrome. Lung biopsy showed patchy loss of endothelial caveolin-1 and von Willebrand factor to occur early. Significant loss of endothelial caveolin-1 was associated with robust expression of caveolin-1 in smooth muscle cells with subsequent neointima formation leading to fatal PAH. Thus, patients who develop acute respiratory distress syndrome after immunosuppressive therapy are at risk of developing PAH.

引用

页码：55 / 58

页数：4