An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders

被引：71

作者：

Yang, Yang ^{[1
,2
]}

Jiang, Shuai ^{[1
]}

Yan, Juanjuan ^{[1
]}

Li, Yue ^{[1
]}

Xin, Zhenlong ^{[1
]}

Lin, Yan ^{[3
]}

Qu, Yan ^{[1
]}

机构：

[1] Fourth Mil Med Univ, Xijing Hosp, Dept Neurosurg, Xian 710032, Peoples R China

[2] Fourth Mil Med Univ, Dept Biomed Engn, Xian 710032, Peoples R China

[3] Fourth Mil Med Univ, Dept Sci Res, Xian 710032, Peoples R China

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Nuclear factor etythroid 2-related factor 2; Cerebrum actions; Molecular mechanisms; Neurodegenerative disorders; TRANSCRIPTION FACTOR NRF2; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NRF2-MEDIATED ANTIOXIDANT RESPONSE; TRANSGENIC MOUSE MODEL; FUMARIC-ACID ESTERS; INDUCED CELL-DEATH; OXIDATIVE STRESS; MULTIPLE-SCLEROSIS; HEME OXYGENASE-1; ALZHEIMERS-DISEASE;

D O I：

10.1016/j.cytogfr.2014.09.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, growing evidence has demonstrated that nuclear factor erythroid 2-related factor 2 (Nrf2) is a pivotal regulator of endogenous defense systems that function via the activation of a set of protective genes, and this is particularly clear in the central nervous system (CNS). Therefore, it is highly useful to summarize the current literature on the molecular mechanisms and role of Nrf2 in the CNS. In this review, we first briefly introduce the molecular features of Nrf2. We then discuss the regulation, cerebral actions, upstream modulators and downstream targets of Nrf2 pathway. Following this background, we expand our discussion to the role of Nrf2 in several major neurodegenerative disorders (NDDs) such as Alzheimer's disease, Parkinson's disease, Huntington's disease, multiple sclerosis and amyotrophic lateral sclerosis. Lastly, we discuss some potential future directions. The information reviewed here may be significant in the design of further experimental research and increase the potential of Nrf2 as a therapeutic target in the future. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：47 / 57

页数：11

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