Spinal neuronal responses to urinary bladder stimulation in rats with corticosterone or aldosterone onto the amygdala

被引:24
|
作者
Qin, C
Greenwood-Van Meerveld, B
Foreman, RD
机构
[1] Univ Oklahoma, Hlth Sci Ctr, Dept Physiol, Oklahoma City, OK 73190 USA
[2] Oklahoma Fdn Digest Res, Basic Sci Labs, Vet Affairs Med Ctr, Oklahoma City, OK 73104 USA
关键词
D O I
10.1152/jn.00298.2003
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Elevating glucocorticoids in the amygdala produces colorectal hypersensitivity through activation of lumbosacral spinal neurons. The aim of this study was to determine if descending modulation from the amygdala affects spinal processing of input from urinary bladder afferents. Fischer-344 rats received cholesterol ( inactive control)-, corticosterone-, or aldosterone-containing micropellets placed stereotaxically on the dorsal margin of the left and right amygdala (n = 10 for each group). Seven days after amygdaloid implantation, extracellular potentials of single L-6-S-1 spinal neurons were examined for the responses to graded (0.5 - 2.0 ml, 20 s) urinary bladder distension (UBD). Spontaneous activity of neurons with excitatory responses to UBD in aldosterone-implanted rats [11.0 +/- 1.7 (SE) imp/s], but not in corticosterone-implanted rats, was higher than in the cholesterol-implanted group (6.6 +/- 1.1 imp/s, P < 0.05). Noxious UBD ( 1.5 ml) produced a greater excitatory response (21.6 +/- 2.6 imp/s) in aldosterone-implanted rats compared with cholesterol- or corticosterone-implanted rats (15.1 +/-1.5 and 13.6 +/- 1.4 imp/s; P < 0.05). In contrast, the duration of excitatory responses to UBD in corticosterone- implanted rats (38.5 +/- 3.4 imp/s) was significantly longer than those in the aldosterone or control groups (26.8 +/- 1.8 and 24.7 +/- 1.5 imp/s). Neurons with low thresholds for excitatory responses to UBD were seen more frequently in aldosterone-implanted rats than in corticosterone or cholesterol treated rats (74 vs. 44% and 39%, P < 0.05). No difference in somatic field properties of spinal neurons responsive or nonresponsive to UBD was found among the three groups. These findings suggest that both mineralocorticoid- and glucocorticoid-mediated mechanisms in the amygdala are involved in descending modulation to lumbosacral spinal neurons receiving inputs from the urinary bladder; and this mechanism may play a role in the activation and maintenance of primary central sensitization to noxious visceral stimuli.
引用
收藏
页码:2180 / 2189
页数:10
相关论文
共 50 条
  • [41] Bladder Responses to Thoracolumbar Epidural Stimulation in Female Urethane-Anesthetized Rats with Graded Contusion Spinal Cord Injuries
    Wilkins, Natasha L.
    Medina-Aguinaga, Daniel
    Hoey, Robert F.
    Fell, Jason
    Harkema, Susan J.
    Hubscher, Charles H.
    JOURNAL OF NEUROTRAUMA, 2025, 42 (3-4) : 229 - 241
  • [42] MOTOR RESPONSES OF URINARY BLADDER AND SKELETAL MUSCLE IN BOTULINUM INTOXICATED RATS
    CARPENTE.FG
    JOURNAL OF PHYSIOLOGY-LONDON, 1967, 188 (01): : 1 - &
  • [43] Alterations in neurogenically mediated contractile responses of urinary bladder in rats with diabetes
    Liu, GM
    Daneshgari, F
    AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2005, 288 (06) : F1220 - F1226
  • [44] The excitatory and inhibitory effects of nitrous oxide on spinal neuronal responses to noxious stimulation
    Antognini, Joseph F.
    Atherley, Richard J.
    Dutton, Robert C.
    Laster, Michael J.
    Eger, Edmond I., II
    Carstens, Earl
    ANESTHESIA AND ANALGESIA, 2007, 104 (04): : 829 - 835
  • [45] EFFECTS OF HALOTHANE ON SPINAL NEURONAL RESPONSES TO GRADED NOXIOUS HEAT STIMULATION IN THE CAT
    NAMIKI, A
    COLLINS, JG
    KITAHATA, LM
    KIKUCHI, H
    HOMMA, E
    THALHAMMER, JG
    ANESTHESIOLOGY, 1980, 53 (06) : 475 - 480
  • [46] RESPONSES OF DENERVATED RAT URINARY-BLADDER TO ALFA-ADRENOCEPTOR STIMULATION
    ELMER, M
    ACTA PHYSIOLOGICA SCANDINAVICA, 1976, 98 (04): : 440 - 444
  • [47] URINARY-BLADDER AND SPHINCTER RESPONSES TO STIMULATION OF DORSAL AND VENTRAL SACRAL ROOTS
    SCHMIDT, RA
    BRUSCHINI, H
    TANAGHO, EA
    INVESTIGATIVE UROLOGY, 1979, 16 (04): : 300 - 304
  • [48] URINARY BLADDER RESPONSES FOLLOWING ELECTRICAL STIMULATION OF ROSTRAL AREAS IN FOREBRAIN OF CAT
    INGERSOL.EH
    JONES, LL
    NEUROLOGY, 1967, 17 (03) : 299 - &
  • [49] RESPONSES OF URINARY BLADDER TO ELECTRICAL STIMULATION OF POINTS IN CEREBELLUM AND MEDULLA OBLONGATA OF CAT
    CRUTE, JA
    INGERSOL.EH
    JONES, LL
    ANATOMICAL RECORD, 1967, 157 (02): : 232 - &
  • [50] URINARY BLADDER RESPONSES TO ELECTRICAL STIMULATION OF POINTS IN CEREBELLUM AND BRAIN STEM OF CAT
    INGERSOL.EH
    CRUTE, JA
    JONES, LL
    ANATOMICAL RECORD, 1968, 160 (02): : 370 - &