One-Pot Sonogashira Coupling-Cyclization toward Regioselective Synthesis of Benzosultams

被引：40

作者：

Debnath, Sudarshan ^{[1
]}

Mondal, Shovan ^{[1
]}

机构：

[1] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 08期

关键词：

11-BETA-HYDROXYSTEROID DEHYDROGENASE; CARBOAMINATION; INHIBITORS; ALKENES;

D O I：

10.1021/acs.joc.5b00274

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A one-pot method for the Sonogashira coupling and cyclization of 2-bromobenzenesulfonamides and terminal alkynes is presented. This method allows access to a variety of substituted benzosultams regioselectively in excellent yields. The reasons for regioselectivity are interpreted through density functional theory (DFT) studies.

引用

页码：3940 / 3948

页数：9

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