microRNAs join the p53 network - another piece in the tumour-suppression puzzle

被引：440

作者：

He, Lin

He, Xingyue

Lowe, Scott W.

Hannon, Gregory J.

机构：

[1] Cold Spring Harbor Lab, Howard Hughes Med Inst, Watson Sch Biol Sci, Cold Spring Harbor, NY 11724 USA

[2] SUNY Stony Brook, Genet Program, Stony Brook, NY 11794 USA

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 11期

关键词：

D O I：

10.1038/nrc2232

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Several recent studies have found a conserved microRNA (miRNA) family, the miR-34s, to be direct transcriptional targets of p53. miR-34 activation can recapitulate elements of p53 activity, including induction of cell-cycle arrest and promotion of apoptosis, and loss of miR-34 can impair p53-mediated cell death. These data reinforce the growing awareness that non-coding RNAs are key players in tumour development by placing miRNAs in a central role in a well-known tumour-suppressor network.

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收藏

页码：819 / 822

页数：4

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