A Spectroscopic Study of the Interaction Between the Bismarck Brown R-Eu(III) Complex and DNA

被引:3
作者
Li, Hongbo [1 ]
Tang, Yongqiong [1 ]
Lei, Shutao [1 ]
You, Zihan [1 ]
Yang, Tianfeng [1 ]
Wang, Suqin [1 ]
机构
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
关键词
Bismarck brown R; Eu(III); DNA; acridine orange; interaction mode; CALF THYMUS DNA; NEUTRAL RED-DYE; FLUORESCENCE PROBE; ACRIDINE-ORANGE; ETHIDIUM-BROMIDE; CRYSTAL-STRUCTURE; TOPOISOMERASE-I; SERUM-ALBUMIN; ACID; BINDING;
D O I
10.1007/s10812-018-0720-7
中图分类号
O433 [光谱学];
学科分类号
0703 ; 070302 ;
摘要
The interaction of the Eu(III)-BBR complex with herring sperm DNA is investigated using an acridine orange (AO) probe for UV-vis absorption spectroscopy and fluorescence spectroscopy. The results indicate that both the AO probe and the Eu(III)-BBR complex can intercalate into the base pairs of DNA. The binding constants of the Eu(III)-BBR complex with DNA are = 1.58 center dot 10(4) L/mol and = 9.35 center dot 10(4) L/mol, and the binding process is entropydriven. It is shown that the interaction modes between the Eu(III)-BBR complex and DNA include groove binding and intercalative binding. The mechanism of the interaction between the Eu(III)-BBR complex and DNA will provide an important theoretical basis for the synthesis of new drugs.
引用
收藏
页码:791 / 799
页数:9
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