A Spectroscopic Study of the Interaction Between the Bismarck Brown R-Eu(III) Complex and DNA

被引：3

作者：

Li, Hongbo ^{[1
]}

Tang, Yongqiong ^{[1
]}

Lei, Shutao ^{[1
]}

You, Zihan ^{[1
]}

Yang, Tianfeng ^{[1
]}

Wang, Suqin ^{[1
]}

机构：

[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China

来源：

JOURNAL OF APPLIED SPECTROSCOPY | 2018年 / 85卷 / 04期

关键词：

Bismarck brown R; Eu(III); DNA; acridine orange; interaction mode; CALF THYMUS DNA; NEUTRAL RED-DYE; FLUORESCENCE PROBE; ACRIDINE-ORANGE; ETHIDIUM-BROMIDE; CRYSTAL-STRUCTURE; TOPOISOMERASE-I; SERUM-ALBUMIN; ACID; BINDING;

D O I：

10.1007/s10812-018-0720-7

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The interaction of the Eu(III)-BBR complex with herring sperm DNA is investigated using an acridine orange (AO) probe for UV-vis absorption spectroscopy and fluorescence spectroscopy. The results indicate that both the AO probe and the Eu(III)-BBR complex can intercalate into the base pairs of DNA. The binding constants of the Eu(III)-BBR complex with DNA are = 1.58 center dot 10(4) L/mol and = 9.35 center dot 10(4) L/mol, and the binding process is entropydriven. It is shown that the interaction modes between the Eu(III)-BBR complex and DNA include groove binding and intercalative binding. The mechanism of the interaction between the Eu(III)-BBR complex and DNA will provide an important theoretical basis for the synthesis of new drugs.

引用

页码：791 / 799

页数：9

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