A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium

被引：45

作者：

Gutman, Boris A. ^{[1
,2
]}

van Erp, Theo G. M. ^{[3
,4
]}

Alpert, Kathryn ^{[5
]}

Ching, Christopher R. K. ^{[6
]}

Isaev, Dmitry ^{[7
]}

Ragothaman, Anjani ^{[8
]}

Jahanshad, Neda ^{[6
]}

Saremi, Arvin ^{[6
]}

Zavaliangos-Petropulu, Artemis ^{[6
]}

Glahn, David C. ^{[9
,10
]}

Shen, Li ^{[11
]}

Cong, Shan ^{[11
]}

Alnaes, Dag ^{[12
,13
]}

Andreassen, Ole Andreas ^{[12
,13
]}

Nhat Trung Doan ^{[12
,13
]}

Westlye, Lars T. ^{[12
,13
,14
]}

Kochunov, Peter ^{[15
]}

Satterthwaite, Theodore D. ^{[16
]}

Wolf, Daniel H. ^{[16
]}

Huang, Alexander J. ^{[3
]}

Kessler, Charles ^{[3
]}

Weideman, Andrea ^{[3
]}

Nguyen, Dana ^{[17
]}

Mueller, Bryon A. ^{[18
]}

Faziola, Lawrence ^{[19
]}

Potkin, Steven G. ^{[19
]}

Preda, Adrian ^{[19
]}

Mathalon, Daniel H. ^{[20
,21
,22
]}

Bustillo, Juan ^{[23
,24
]}

Calhoun, Vince ^{[25
,26
]}

Ford, Judith M. ^{[22
,27
]}

Walton, Esther ^{[28
]}

Ehrlich, Stefan ^{[29
]}

Ducci, Giuseppe ^{[30
]}

Banaj, Nerisa ^{[31
]}

Piras, Fabrizio ^{[31
]}

Piras, Federica ^{[31
]}

Spalletta, Gianfranco ^{[31
,32
]}

Canales-Rodriguez, Erick J. ^{[33
]}

Fuentes-Claramonte, Paola ^{[33
]}

Pomarol-Clotet, Edith ^{[33
]}

Radua, Joaquim ^{[33
,34
]}

Salvador, Raymond ^{[33
]}

Sarro, Salvador ^{[33
]}

Dickie, Erin W. ^{[35
]}

Voineskos, Aristotle ^{[35
]}

Tordesillas-Gutierrez, Diana ^{[36
]}

Crespo-Facorro, Benedicto ^{[37
]}

Setien-Suero, Esther ^{[38
]}

van Son, Jacqueline Mayoral ^{[37
]}

机构：

[1] IIT, Dept Biomed Engn, Chicago, IL 60616 USA

[2] Kharkevich Inst, Inst Informat Transmiss Problems, Moscow, Russia

[3] Univ Calif Irvine, Dept Psychiat & Human Behav, Clin Translat Neurosci Lab, Irvine, CA USA

[4] Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA

[5] Northwestern Univ, Feinberg Sch Med, Dept Psychiat & Behav Sci, 710 N Lake Shore Dr,Abbott Hall 1322, Chicago, IL 60611 USA

[6] Univ Southern Calif, Keck Sch Med, Mark & Mary Stevens Neuroimaging & Informat Inst, Imaging Genet Ctr, Los Angeles, CA 90007 USA

[7] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[8] Oregon Hlth & Sci Univ, Dept Biomed Engn, Portland, OR 97201 USA

[9] Boston Childrens Hosp, Dept Psychiat, Boston, MA USA

[10] Harvard Med Sch, Boston, MA 02115 USA

[11] Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA

[12] Univ Oslo, Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT, Oslo, Norway

[13] Univ Oslo, Inst Clin Med, Oslo, Norway

[14] Univ Oslo, Dept Psychol, Oslo, Norway

[15] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

[16] Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA

[17] Univ Calif Irvine, Dept Pediat, Irvine, CA 92717 USA

[18] Univ Minnesota, Dept Psychiat & Behav Sci, Minneapolis, MN USA

[19] Univ Calif Irvine, Dept Psychiat & Human Behav, Irvine, CA 92717 USA

[20] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[21] Univ Calif San Francisco, Weill Inst Neurosci, San Francisco, CA 94143 USA

[22] VA San Francisco Healthcare Syst, Judith Ford Mental Hlth, San Francisco, CA USA

[23] Univ New Mexico, Dept Psychiat, Albuquerque, NM USA

[24] Univ New Mexico, Dept Neurosci, Albuquerque, NM 87131 USA

[25] Emory Univ, Georgia Inst Technol, Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA

[26] Univ New Mexico, Dept Elect & Comp Engn, Albuquerque, NM 87131 USA

[27] Univ Calif San Francisco, Dept Psychiat & Behav Sci, San Francisco, CA 94143 USA

[28] Univ Bath, Dept Psychol, Bath, Avon, England

[29] Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany

[30] ASL Roma1 DSM, Mental Hlth Dept, Rome, Italy

[31] IRCCS Santa Lucia Fdn, Lab Neuropsychiat, Rome, Italy

[32] Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

[33] CIBERSAM, FIDMAG Germanes Hosp Res Fdn, Barcelona, Spain

[34] Inst Invest Biomd August Pi & Sunyer IDIBAPS, Barcelona, Spain

[35] Ctr Addict & Mental Hlth CAMH, Toronto, ON, Canada

[36] Marques de Valdecilla Univ Hosp, Dept Radiol, IDIVAL, Santander, Spain

[37] Univ Seville, Univ Hosp Virgen del Rocio, CIBERSAM, IBiS, Seville, Spain

[38] Univ Hosp Marques de Valdecilla, CIBERSAM, IDIVAL, Santander, Spain

[39] Univ Basel, Dept Psychiat, Basel, Switzerland

[40] Univ Lubeck, Dept Psychiat & Psychotherapy, Lubeck, Germany

[41] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom, Discipline Biochem, Galway, Ireland

[42] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom, Sch Psychol, Galway, Ireland

[43] Natl Univ Ireland Galway, Ctr Neuroimaging & Cognit Genom, Clin Neuroimaging Lab, Galway, Ireland

[44] Trinity Coll Dublin, Dept Psychiat, Neuropsychiat Genet Res Grp, Dublin, Ireland

[45] Trinity Coll Dublin, Trinity Coll Inst Neurosci, Dublin, Ireland

[46] Univ Sao Paulo, Hosp Clin HCFMUSP, Fac Med, Dept & Inst Psiquiatria,Lab Psychiat Neuroimaging, Sao Paulo, SP, Brazil

[47] Hosp Sirio Libanes, Sao Paulo, SP, Brazil

[48] Mental Hlth Res Ctr, Lab Neuroimaging & Multimodal Anal, Moscow, Russia

[49] Mental Hlth Res Ctr, Dept Endogenous Mental Disorders, Moscow, Russia

[50] Univ Oxford, Dept Psychiat, Oxford, England

来源：

HUMAN BRAIN MAPPING | 2022年 / 43卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

schizophrenia; structure; subcortical shape; CORTICAL THICKNESS; HIPPOCAMPAL SHAPE; 1ST-EPISODE SCHIZOPHRENIA; BASAL GANGLIA; ANTIPSYCHOTIC TREATMENT; GENETIC INFLUENCES; THALAMIC VOLUME; TEMPORAL-LOBE; NEURONS; NETWORK;

D O I：

10.1002/hbm.25625

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Schizophrenia is associated with widespread alterations in subcortical brain structure. While analytic methods have enabled more detailed morphometric characterization, findings are often equivocal. In this meta-analysis, we employed the harmonized ENIGMA shape analysis protocols to collaboratively investigate subcortical brain structure shape differences between individuals with schizophrenia and healthy control participants. The study analyzed data from 2,833 individuals with schizophrenia and 3,929 healthy control participants contributed by 21 worldwide research groups participating in the ENIGMA Schizophrenia Working Group. Harmonized shape analysis protocols were applied to each site's data independently for bilateral hippocampus, amygdala, caudate, accumbens, putamen, pallidum, and thalamus obtained from T1-weighted structural MRI scans. Mass univariate meta-analyses revealed more-concave-than-convex shape differences in the hippocampus, amygdala, accumbens, and thalamus in individuals with schizophrenia compared with control participants, more-convex-than-concave shape differences in the putamen and pallidum, and both concave and convex shape differences in the caudate. Patterns of exaggerated asymmetry were observed across the hippocampus, amygdala, and thalamus in individuals with schizophrenia compared to control participants, while diminished asymmetry encompassed ventral striatum and ventral and dorsal thalamus. Our analyses also revealed that higher chlorpromazine dose equivalents and increased positive symptom levels were associated with patterns of contiguous convex shape differences across multiple subcortical structures. Findings from our shape meta-analysis suggest that common neurobiological mechanisms may contribute to gray matter reduction across multiple subcortical regions, thus enhancing our understanding of the nature of network disorganization in schizophrenia.

引用

页码：352 / 372

页数：21

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