Immunization with radioattenuated yeast cells of Paracoccidioides brasiliensis induces a long lasting protection in BALB/c mice

被引：13

作者：

Martins, Estefania Mara do Nascimento

Reis, Bernardo Sgarbi

Fernandes, Viviane Cristina

Costa, Miriam Maria Silva

Goes, Alfredo Miranda

de Andrade, Antero Silva Ribeiro

机构：

[1] Ctr Desenvolvimento Tecnol Nucl, Radiobiol Lab, BR-30123970 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Bioquim & Imunol, BR-32270901 Belo Horizonte, MG, Brazil

来源：

VACCINE | 2007年 / 25卷 / 46期

关键词：

Paracoccidioides brasiliensis; vaccine; gamma irradiation; ANTIGENS; IMMUNITY; GENE; GP43;

D O I：

10.1016/j.vaccine.2007.09.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Paracoccidioides brasiliensis is the fungus agent of paracoccidioidomycosis, a chronic systemic disease prevalent in Latin America. The aim of the present work was to evaluate the protection elicited by the immunization of BALB/c mice with radioattenuated yeast cells of P. brasiliensis. The immunization promoted a long lasting protection against highly infective yeast forms of P brasiliensis. A 99.5% decrease in CFUs recovery was verified 90 days post challenge. At the same time the levels of IgG2a and IFN-gamma were high while a very low production of IL-10 and IL-5 was verified, suggesting that a Th1 pattern was dominant. This work shows the potential of radioattenuated yeast cells for the development of vaccines against fungi infections. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7893 / 7899

页数：7

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