Application of phage peptide display technology for the study of food allergen epitopes

被引：25

作者：

Chen, Xueni ^{[1
]}

Dreskin, Stephen C.

机构：

[1] Univ Colorado Denver, Div Allergy & Clin Immunol, Dept Med, Aurora, CO 80204 USA

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2017年 / 61卷 / 06期

关键词：

Food allergy; Conformational epitope; IgE epitope; Mimotopes; Phage peptide display; ARA H 2; LIPID TRANSFER PROTEIN; CONFORMATIONAL IGE EPITOPES; MICROARRAY IMMUNOASSAY; CROSS-REACTIVITY; PEANUT ALLERGEN; MAJOR ALLERGEN; IN-VITRO; ANTIBODY INTERACTIONS; MUTAGENESIS APPROACH;

D O I：

10.1002/mnfr.201600568

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Phage peptide display technology has been used to identify IgE-binding mimotopes (mimics of natural epitopes) that mimic conformational epitopes. This approach is effective in the characterization of those epitopes that are important for eliciting IgE-mediated allergic responses by food allergens and those that are responsible for cross-reactivity among allergenic food proteins. Application of this technology will increase our understanding of the mechanisms whereby food allergens elicit allergic reactions, will facilitate the discovery of diagnostic reagents and may lead to mimotope-based immunotherapy.

引用

页数：9

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